TISIDB

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Apical cell membrane Multi-pass membrane protein
Domain	PF00664 ABC transporter transmembrane region PF00005 ABC transporter
Function	Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

> Gene Ontology [ TOP ]
Biological Process	GO:0001101 response to acid chemical GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006855 drug transmembrane transport GO:0006869 lipid transport GO:0006979 response to oxidative stress GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015723 bilirubin transport GO:0015732 prostaglandin transport GO:0015893 drug transport GO:0015908 fatty acid transport GO:0030002 cellular anion homeostasis GO:0030320 cellular monovalent inorganic anion homeostasis GO:0030644 cellular chloride ion homeostasis GO:0031427 response to methotrexate GO:0042493 response to drug GO:0043627 response to estrogen GO:0046685 response to arsenic-containing substance GO:0046942 carboxylic acid transport GO:0048545 response to steroid hormone GO:0055064 chloride ion homeostasis GO:0055081 anion homeostasis GO:0055083 monovalent inorganic anion homeostasis GO:0070327 thyroid hormone transport GO:0071715 icosanoid transport GO:0072337 modified amino acid transport GO:0098656 anion transmembrane transport
Molecular Function	GO:0005310 dicarboxylic acid transmembrane transporter activity GO:0005342 organic acid transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015127 bilirubin transmembrane transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043225 ATPase-coupled anion transmembrane transporter activity GO:0043492 ATPase activity, coupled to movement of substances GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component	GO:0016324 apical plasma membrane GO:0045177 apical part of cell

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa02010 ABC transporters hsa04976 Bile secretion
Reactome	R-HSA-382556: ABC-family proteins mediated transport R-HSA-382551: Transmembrane transport of small molecules

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ABCC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ABCC2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ABCC2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	1.221	0.0587
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	2.472	0.0253
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.303	0.761
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.432	0.337
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.069	0.463
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.368	0.829
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	1.636	0.0242
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.216	0.354
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	2.024	0.18
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.179	0.878
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.02	0.99
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.113	0.567

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ABCC2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	5.5	1.9	0.66
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	6.8	0.6	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCC2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ABCC2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ABCC2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ABCC2
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases	DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location	10q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ABCC2 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting ABCC2.

ID	Name	Drug Type	Targets	#Targets
DB00171	ATP	Small Molecule	ABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......	42
DB01138	Sulfinpyrazone	Small Molecule	ABCC1, ABCC2, NR1I2, SLC22A12	4

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