Browse ACVR1C

Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type I membrane protein
Domain PF07714 Protein tyrosine kinase
PF08515 Transforming growth factor beta type I GS-motif
Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

> Gene Ontology
 
Biological Process GO:0001667 ameboidal-type cell migration
GO:0002021 response to dietary excess
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007565 female pregnancy
GO:0007566 embryo implantation
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0015833 peptide transport
GO:0019915 lipid storage
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030262 apoptotic nuclear changes
GO:0030336 negative regulation of cell migration
GO:0031667 response to nutrient levels
GO:0032868 response to insulin
GO:0032924 activin receptor signaling pathway
GO:0034284 response to monosaccharide
GO:0038092 nodal signaling pathway
GO:0040013 negative regulation of locomotion
GO:0042886 amide transport
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434 response to peptide hormone
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0044706 multi-multicellular organism process
GO:0045862 positive regulation of proteolysis
GO:0046676 negative regulation of insulin secretion
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051224 negative regulation of protein transport
GO:0051235 maintenance of location
GO:0051271 negative regulation of cellular component movement
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0061450 trophoblast cell migration
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0097194 execution phase of apoptosis
GO:0097360 chorionic trophoblast cell proliferation
GO:1901163 regulation of trophoblast cell migration
GO:1901164 negative regulation of trophoblast cell migration
GO:1901382 regulation of chorionic trophoblast cell proliferation
GO:1901383 negative regulation of chorionic trophoblast cell proliferation
GO:1901652 response to peptide
GO:1903531 negative regulation of secretion by cell
GO:1904950 negative regulation of establishment of protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000146 negative regulation of cell motility
GO:2000241 regulation of reproductive process
GO:2000242 negative regulation of reproductive process
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0005057 receptor signaling protein activity
GO:0016361 activin receptor activity, type I
GO:0017002 activin-activated receptor activity
GO:0019199 transmembrane receptor protein kinase activity
GO:0019838 growth factor binding
GO:0038100 nodal binding
Cellular Component GO:0043235 receptor complex
GO:0048179 activin receptor complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0098802 plasma membrane receptor complex
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
> KEGG and Reactome Pathway
 
KEGG hsa04350 TGF-beta signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome R-HSA-1266738: Developmental Biology
R-HSA-1433617: Regulation of signaling by NODAL
R-HSA-162582: Signal Transduction
R-HSA-1502540: Signaling by Activin
R-HSA-1181150: Signaling by NODAL
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ACVR1C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ACVR1C in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ACVR1C in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0210.909
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0820.847
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0230.945
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.3570.0212
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.4380.0238
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 4701
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.4880.00999
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.3940.0118
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5010.636
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4230.351
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0180.115
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3660.126
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ACVR1C in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACVR1C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACVR1C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACVR1C.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACVR1C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ACVR1C expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ACVR1C and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolACVR1C
Nameactivin A receptor, type IC
Aliases ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ACVR1C collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.