Browse ADIPOQ

Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00386 C1q domain
PF01391 Collagen triple helix repeat (20 copies)
Function

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001666 response to hypoxia
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001933 negative regulation of protein phosphorylation
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002064 epithelial cell development
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006094 gluconeogenesis
GO:0006109 regulation of carbohydrate metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006469 negative regulation of protein kinase activity
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0006979 response to oxidative stress
GO:0007009 plasma membrane organization
GO:0007162 negative regulation of cell adhesion
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007369 gastrulation
GO:0007584 response to nutrient
GO:0007623 circadian rhythm
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009062 fatty acid catabolic process
GO:0009743 response to carbohydrate
GO:0009744 response to sucrose
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009755 hormone-mediated signaling pathway
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010470 regulation of gastrulation
GO:0010565 regulation of cellular ketone metabolic process
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010677 negative regulation of cellular carbohydrate metabolic process
GO:0010720 positive regulation of cell development
GO:0010737 protein kinase A signaling
GO:0010738 regulation of protein kinase A signaling
GO:0010739 positive regulation of protein kinase A signaling
GO:0010742 macrophage derived foam cell differentiation
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010828 positive regulation of glucose transport
GO:0010869 regulation of receptor biosynthetic process
GO:0010871 negative regulation of receptor biosynthetic process
GO:0010874 regulation of cholesterol efflux
GO:0010875 positive regulation of cholesterol efflux
GO:0010876 lipid localization
GO:0010906 regulation of glucose metabolic process
GO:0014074 response to purine-containing compound
GO:0014812 muscle cell migration
GO:0014823 response to activity
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015850 organic hydroxy compound transport
GO:0015918 sterol transport
GO:0016042 lipid catabolic process
GO:0016051 carbohydrate biosynthetic process
GO:0016054 organic acid catabolic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0019395 fatty acid oxidation
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0023061 signal release
GO:0030099 myeloid cell differentiation
GO:0030100 regulation of endocytosis
GO:0030225 macrophage differentiation
GO:0030258 lipid modification
GO:0030301 cholesterol transport
GO:0030336 negative regulation of cell migration
GO:0030851 granulocyte differentiation
GO:0030852 regulation of granulocyte differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0031348 negative regulation of defense response
GO:0031667 response to nutrient levels
GO:0031952 regulation of protein autophosphorylation
GO:0031953 negative regulation of protein autophosphorylation
GO:0031960 response to corticosteroid
GO:0032091 negative regulation of protein binding
GO:0032102 negative regulation of response to external stimulus
GO:0032368 regulation of lipid transport
GO:0032370 positive regulation of lipid transport
GO:0032371 regulation of sterol transport
GO:0032373 positive regulation of sterol transport
GO:0032374 regulation of cholesterol transport
GO:0032376 positive regulation of cholesterol transport
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032602 chemokine production
GO:0032637 interleukin-8 production
GO:0032640 tumor necrosis factor production
GO:0032642 regulation of chemokine production
GO:0032677 regulation of interleukin-8 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032757 positive regulation of interleukin-8 production
GO:0032799 low-density lipoprotein receptor particle metabolic process
GO:0032800 receptor biosynthetic process
GO:0032835 glomerulus development
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033002 muscle cell proliferation
GO:0033028 myeloid cell apoptotic process
GO:0033032 regulation of myeloid cell apoptotic process
GO:0033034 positive regulation of myeloid cell apoptotic process
GO:0033157 regulation of intracellular protein transport
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033211 adiponectin-activated signaling pathway
GO:0033344 cholesterol efflux
GO:0033500 carbohydrate homeostasis
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034113 heterotypic cell-cell adhesion
GO:0034114 regulation of heterotypic cell-cell adhesion
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034284 response to monosaccharide
GO:0034285 response to disaccharide
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0034440 lipid oxidation
GO:0034612 response to tumor necrosis factor
GO:0035690 cellular response to drug
GO:0035787 cell migration involved in kidney development
GO:0035788 cell migration involved in metanephros development
GO:0035789 metanephric mesenchymal cell migration
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0036293 response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0042180 cellular ketone metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042391 regulation of membrane potential
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043112 receptor metabolic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043393 regulation of protein binding
GO:0043405 regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0044057 regulation of system process
GO:0044242 cellular lipid catabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045444 fat cell differentiation
GO:0045471 response to ethanol
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045649 regulation of macrophage differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045713 low-density lipoprotein particle receptor biosynthetic process
GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045721 negative regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0045806 negative regulation of endocytosis
GO:0045834 positive regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045912 negative regulation of carbohydrate metabolic process
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045995 regulation of embryonic development
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0046364 monosaccharide biosynthetic process
GO:0046395 carboxylic acid catabolic process
GO:0046683 response to organophosphorus
GO:0046777 protein autophosphorylation
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048511 rhythmic process
GO:0048545 response to steroid hormone
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050765 negative regulation of phagocytosis
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050873 brown fat cell differentiation
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051224 negative regulation of protein transport
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051271 negative regulation of cellular component movement
GO:0051291 protein heterooligomerization
GO:0051348 negative regulation of transferase activity
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0051899 membrane depolarization
GO:0060081 membrane hyperpolarization
GO:0060627 regulation of vesicle-mediated transport
GO:0060759 regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0061005 cell differentiation involved in kidney development
GO:0061318 renal filtration cell differentiation
GO:0070206 protein trimerization
GO:0070208 protein heterotrimerization
GO:0070293 renal absorption
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070482 response to oxygen levels
GO:0070543 response to linoleic acid
GO:0070586 cell-cell adhesion involved in gastrulation
GO:0070587 regulation of cell-cell adhesion involved in gastrulation
GO:0070994 detection of oxidative stress
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071375 cellular response to peptide hormone stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071605 monocyte chemotactic protein-1 production
GO:0071637 regulation of monocyte chemotactic protein-1 production
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071867 response to monoamine
GO:0071868 cellular response to monoamine stimulus
GO:0071869 response to catecholamine
GO:0071870 cellular response to catecholamine stimulus
GO:0071871 response to epinephrine
GO:0071872 cellular response to epinephrine stimulus
GO:0071897 DNA biosynthetic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072010 glomerular epithelium development
GO:0072015 glomerular visceral epithelial cell development
GO:0072073 kidney epithelium development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072202 cell differentiation involved in metanephros development
GO:0072207 metanephric epithelium development
GO:0072210 metanephric nephron development
GO:0072215 regulation of metanephros development
GO:0072216 positive regulation of metanephros development
GO:0072217 negative regulation of metanephros development
GO:0072224 metanephric glomerulus development
GO:0072243 metanephric nephron epithelium development
GO:0072244 metanephric glomerular epithelium development
GO:0072248 metanephric glomerular visceral epithelial cell differentiation
GO:0072249 metanephric glomerular visceral epithelial cell development
GO:0072298 regulation of metanephric glomerulus development
GO:0072300 positive regulation of metanephric glomerulus development
GO:0072310 glomerular epithelial cell development
GO:0072311 glomerular epithelial cell differentiation
GO:0072312 metanephric glomerular epithelial cell differentiation
GO:0072313 metanephric glomerular epithelial cell development
GO:0072329 monocarboxylic acid catabolic process
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090077 foam cell differentiation
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0090185 negative regulation of kidney development
GO:0090192 regulation of glomerulus development
GO:0090193 positive regulation of glomerulus development
GO:0090317 negative regulation of intracellular protein transport
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0097017 renal protein absorption
GO:0097018 renal albumin absorption
GO:0097305 response to alcohol
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0098801 regulation of renal system process
GO:1900120 regulation of receptor binding
GO:1900121 negative regulation of receptor binding
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902532 negative regulation of intracellular signal transduction
GO:1903531 negative regulation of secretion by cell
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903828 negative regulation of cellular protein localization
GO:1904950 negative regulation of establishment of protein localization
GO:1990778 protein localization to cell periphery
GO:2000146 negative regulation of cell motility
GO:2000278 regulation of DNA biosynthetic process
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000465 regulation of glycogen (starch) synthase activity
GO:2000467 positive regulation of glycogen (starch) synthase activity
GO:2000477 regulation of metanephric glomerular visceral epithelial cell development
GO:2000478 positive regulation of metanephric glomerular visceral epithelial cell development
GO:2000479 regulation of cAMP-dependent protein kinase activity
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000532 regulation of renal albumin absorption
GO:2000534 positive regulation of renal albumin absorption
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000589 regulation of metanephric mesenchymal cell migration
GO:2000590 negative regulation of metanephric mesenchymal cell migration
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
GO:2000698 positive regulation of epithelial cell differentiation involved in kidney development
Molecular Function GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0031406 carboxylic acid binding
GO:0033691 sialic acid binding
GO:0043168 anion binding
Cellular Component GO:0005581 collagen trimer
> KEGG and Reactome Pathway
 
KEGG hsa03320 PPAR signaling pathway
hsa04152 AMPK signaling pathway
hsa04920 Adipocytokine signaling pathway
Reactome R-HSA-163680: AMPK inhibits chREBP transcriptional activation activity
R-HSA-1266738: Developmental Biology
R-HSA-163685: Integration of energy metabolism
R-HSA-1430728: Metabolism
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ADIPOQ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ADIPOQ and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23530146LymphomaInhibit immunity (NK cell function)Previously, we found that adiponectin (APN) suppresses IL-2-induced NK cell activation by downregulating the expression of the IFN-γ-inducible TNF-related apoptosis-inducing ligand and Fas ligand. In this study, we assessed the role of APN in immune cell function, including NK cells, CTLs, and myeloid-derived suppressor cells, in EL4 and B16F10 tumor-bearing APN knockout (KO) mice. In APNKO mice, splenic NK cells showed enhanced cytotoxicity with and without IL-2 stimulation.
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ADIPOQ in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ADIPOQ in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2690.687
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.210.837
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2820.751
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.4350.0553
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6360.232
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.1830.461
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-2.0790.125
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7220.7
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-3.1910.117
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.5430.158
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 283.1850.019
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2980.465
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ADIPOQ in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADIPOQ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADIPOQ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADIPOQ.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADIPOQ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ADIPOQ expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ADIPOQ and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolADIPOQ
Nameadiponectin, C1Q and collagen domain containing
Aliases ACRP30; GBP28; adiponectin; adipose most abundant gene transcript 1; adiponectin precursor; ACDC; adipocyte, ......
Chromosomal Location3q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ADIPOQ collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.