Browse AGT

Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00079 Serpin (serine protease inhibitor)
Function

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; FUNCTION: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; FUNCTION: Angiotensin-3: stimulates aldosterone release.; FUNCTION: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001667 ameboidal-type cell migration
GO:0001763 morphogenesis of a branching structure
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001974 blood vessel remodeling
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure
GO:0001990 regulation of systemic arterial blood pressure by hormone
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002002 regulation of angiotensin levels in blood
GO:0002003 angiotensin maturation
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002019 regulation of renal output by angiotensin
GO:0002027 regulation of heart rate
GO:0002034 regulation of blood vessel size by renin-angiotensin
GO:0002035 brain renin-angiotensin system
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003015 heart process
GO:0003018 vascular process in circulatory system
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0003051 angiotensin-mediated drinking behavior
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0003298 physiological muscle hypertrophy
GO:0003300 cardiac muscle hypertrophy
GO:0003301 physiological cardiac muscle hypertrophy
GO:0003330 regulation of extracellular matrix constituent secretion
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006606 protein import into nucleus
GO:0006801 superoxide metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006816 calcium ion transport
GO:0006865 amino acid transport
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006883 cellular sodium ion homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0007043 cell-cell junction assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 JAK-STAT cascade
GO:0007263 nitric oxide mediated signal transduction
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0007588 excretion
GO:0007631 feeding behavior
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008202 steroid metabolic process
GO:0008217 regulation of blood pressure
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0009914 hormone transport
GO:0010466 negative regulation of peptidase activity
GO:0010517 regulation of phospholipase activity
GO:0010518 positive regulation of phospholipase activity
GO:0010533 regulation of activation of Janus kinase activity
GO:0010534 regulation of activation of JAK2 kinase activity
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010611 regulation of cardiac muscle hypertrophy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010657 muscle cell apoptotic process
GO:0010658 striated muscle cell apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0010660 regulation of muscle cell apoptotic process
GO:0010661 positive regulation of muscle cell apoptotic process
GO:0010662 regulation of striated muscle cell apoptotic process
GO:0010663 positive regulation of striated muscle cell apoptotic process
GO:0010665 regulation of cardiac muscle cell apoptotic process
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010742 macrophage derived foam cell differentiation
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010805 regulation of lysine import
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010828 positive regulation of glucose transport
GO:0010863 positive regulation of phospholipase C activity
GO:0010872 regulation of cholesterol esterification
GO:0010873 positive regulation of cholesterol esterification
GO:0010876 lipid localization
GO:0010951 negative regulation of endopeptidase activity
GO:0010958 regulation of amino acid import
GO:0010959 regulation of metal ion transport
GO:0010963 regulation of L-arginine import
GO:0014061 regulation of norepinephrine secretion
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014706 striated muscle tissue development
GO:0014742 positive regulation of muscle hypertrophy
GO:0014743 regulation of muscle hypertrophy
GO:0014812 muscle cell migration
GO:0014820 tonic smooth muscle contraction
GO:0014823 response to activity
GO:0014824 artery smooth muscle contraction
GO:0014829 vascular smooth muscle contraction
GO:0014850 response to muscle activity
GO:0014873 response to muscle activity involved in regulation of muscle adaptation
GO:0014874 response to stimulus involved in regulation of muscle adaptation
GO:0014896 muscle hypertrophy
GO:0014897 striated muscle hypertrophy
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015837 amine transport
GO:0015844 monoamine transport
GO:0015849 organic acid transport
GO:0015850 organic hydroxy compound transport
GO:0015874 norepinephrine transport
GO:0016049 cell growth
GO:0016264 gap junction assembly
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0016525 negative regulation of angiogenesis
GO:0017038 protein import
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019226 transmission of nerve impulse
GO:0019229 regulation of vasoconstriction
GO:0019932 second-messenger-mediated signaling
GO:0023061 signal release
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030198 extracellular matrix organization
GO:0030258 lipid modification
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031349 positive regulation of defense response
GO:0031644 regulation of neurological system process
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032368 regulation of lipid transport
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032890 regulation of organic acid transport
GO:0032892 positive regulation of organic acid transport
GO:0032928 regulation of superoxide anion generation
GO:0032930 positive regulation of superoxide anion generation
GO:0033002 muscle cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0033860 regulation of NAD(P)H oxidase activity
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034103 regulation of tissue remodeling
GO:0034104 negative regulation of tissue remodeling
GO:0034226 lysine import
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034367 macromolecular complex remodeling
GO:0034368 protein-lipid complex remodeling
GO:0034369 plasma lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034433 steroid esterification
GO:0034434 sterol esterification
GO:0034435 cholesterol esterification
GO:0034504 protein localization to nucleus
GO:0035051 cardiocyte differentiation
GO:0035150 regulation of tube size
GO:0035239 tube morphogenesis
GO:0035265 organ growth
GO:0035411 catenin import into nucleus
GO:0035637 multicellular organismal signaling
GO:0035812 renal sodium excretion
GO:0035813 regulation of renal sodium excretion
GO:0035815 positive regulation of renal sodium excretion
GO:0035929 steroid hormone secretion
GO:0035930 corticosteroid hormone secretion
GO:0035931 mineralocorticoid secretion
GO:0035932 aldosterone secretion
GO:0038127 ERBB signaling pathway
GO:0038179 neurotrophin signaling pathway
GO:0040017 positive regulation of locomotion
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0042445 hormone metabolic process
GO:0042554 superoxide anion generation
GO:0042692 muscle cell differentiation
GO:0042756 drinking behavior
GO:0042976 activation of Janus kinase activity
GO:0042977 activation of JAK2 kinase activity
GO:0043062 extracellular structure organization
GO:0043090 amino acid import
GO:0043091 L-arginine import
GO:0043092 L-amino acid import
GO:0043434 response to peptide hormone
GO:0043500 muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0043542 endothelial cell migration
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044062 regulation of excretion
GO:0044089 positive regulation of cellular component biogenesis
GO:0044381 glucose import in response to insulin stimulus
GO:0044706 multi-multicellular organism process
GO:0044744 protein targeting to nucleus
GO:0045216 cell-cell junction organization
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045765 regulation of angiogenesis
GO:0045777 positive regulation of blood pressure
GO:0045834 positive regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045909 positive regulation of vasodilation
GO:0045926 negative regulation of growth
GO:0045940 positive regulation of steroid metabolic process
GO:0046209 nitric oxide metabolic process
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048243 norepinephrine secretion
GO:0048514 blood vessel morphogenesis
GO:0048588 developmental cell growth
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048738 cardiac muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048771 tissue remodeling
GO:0050432 catecholamine secretion
GO:0050433 regulation of catecholamine secretion
GO:0050663 cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of synaptic transmission
GO:0050880 regulation of blood vessel size
GO:0050886 endocrine process
GO:0051047 positive regulation of secretion
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051272 positive regulation of cellular component movement
GO:0051341 regulation of oxidoreductase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051386 regulation of neurotrophin TRK receptor signaling pathway
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051604 protein maturation
GO:0051924 regulation of calcium ion transport
GO:0051937 catecholamine transport
GO:0051952 regulation of amine transport
GO:0051954 positive regulation of amine transport
GO:0051955 regulation of amino acid transport
GO:0051957 positive regulation of amino acid transport
GO:0051969 regulation of transmission of nerve impulse
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055006 cardiac cell development
GO:0055007 cardiac muscle cell differentiation
GO:0055013 cardiac muscle cell development
GO:0055017 cardiac muscle tissue growth
GO:0055067 monovalent inorganic cation homeostasis
GO:0055074 calcium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0060047 heart contraction
GO:0060177 regulation of angiotensin metabolic process
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0060419 heart growth
GO:0060537 muscle tissue development
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060986 endocrine hormone secretion
GO:0060993 kidney morphogenesis
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061138 morphogenesis of a branching epithelium
GO:0061213 positive regulation of mesonephros development
GO:0061217 regulation of mesonephros development
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061337 cardiac conduction
GO:0061461 L-lysine import
GO:0070278 extracellular matrix constituent secretion
GO:0070371 ERK1 and ERK2 cascade
GO:0070471 uterine smooth muscle contraction
GO:0070838 divalent metal ion transport
GO:0071214 cellular response to abiotic stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071496 cellular response to external stimulus
GO:0071825 protein-lipid complex subunit organization
GO:0071827 plasma lipoprotein particle organization
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072593 reactive oxygen species metabolic process
GO:0085029 extracellular matrix assembly
GO:0090066 regulation of anatomical structure size
GO:0090077 foam cell differentiation
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0090189 regulation of branching involved in ureteric bud morphogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090257 regulation of muscle system process
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0090322 regulation of superoxide metabolic process
GO:0090467 arginine import
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097696 STAT cascade
GO:0098657 import into cell
GO:0098801 regulation of renal system process
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900078 positive regulation of cellular response to insulin stimulus
GO:1900274 regulation of phospholipase C activity
GO:1901042 positive regulation of L-arginine import
GO:1901184 regulation of ERBB signaling pathway
GO:1901186 positive regulation of ERBB signaling pathway
GO:1901201 regulation of extracellular matrix assembly
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901888 regulation of cell junction assembly
GO:1901890 positive regulation of cell junction assembly
GO:1902022 L-lysine transport
GO:1902023 L-arginine transport
GO:1902593 single-organism nuclear import
GO:1902765 L-arginine import into cell
GO:1902826 regulation of L-arginine import into cell
GO:1902828 positive regulation of L-arginine import into cell
GO:1902837 amino acid import into cell
GO:1903053 regulation of extracellular matrix organization
GO:1903055 positive regulation of extracellular matrix organization
GO:1903409 reactive oxygen species biosynthetic process
GO:1903410 L-lysine import into cell
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903532 positive regulation of secretion by cell
GO:1903596 regulation of gap junction assembly
GO:1903598 positive regulation of gap junction assembly
GO:1903779 regulation of cardiac conduction
GO:1904407 positive regulation of nitric oxide metabolic process
GO:1904705 regulation of vascular smooth muscle cell proliferation
GO:1904707 positive regulation of vascular smooth muscle cell proliferation
GO:1904738 vascular associated smooth muscle cell migration
GO:1904752 regulation of vascular associated smooth muscle cell migration
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1905008 regulation of L-lysine import into cell
GO:1905010 positive regulation of L-lysine import into cell
GO:1905330 regulation of morphogenesis of an epithelium
GO:1905332 positive regulation of morphogenesis of an epithelium
GO:1990874 vascular smooth muscle cell proliferation
GO:2000021 regulation of ion homeostasis
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000831 regulation of steroid hormone secretion
GO:2000846 regulation of corticosteroid hormone secretion
GO:2000855 regulation of mineralocorticoid secretion
GO:2000858 regulation of aldosterone secretion
GO:2001057 reactive nitrogen species metabolic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001273 regulation of glucose import in response to insulin stimulus
GO:2001275 positive regulation of glucose import in response to insulin stimulus
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0004857 enzyme inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005179 hormone activity
GO:0008083 growth factor activity
GO:0030414 peptidase inhibitor activity
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031703 type 2 angiotensin receptor binding
GO:0061134 peptidase regulator activity
GO:0061135 endopeptidase regulator activity
Cellular Component GO:0072562 blood microparticle
> KEGG and Reactome Pathway
 
KEGG hsa04614 Renin-angiotensin system
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-418594: G alpha (i) signalling events
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-1430728: Metabolism
R-HSA-2022377: Metabolism of Angiotensinogen to Angiotensins
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-1989781: PPARA activates gene expression
R-HSA-2980736: Peptide hormone metabolism
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AGT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AGT in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AGT in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4340.562
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8230.536
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.3690.174
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4040.598
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.960.117
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.5710.342
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.680.418
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.3770.251
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1880.886
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6760.709
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0270.993
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6390.0239
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AGT in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AGT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AGT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AGT.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AGT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AGT expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AGT and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAGT
Nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Aliases SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ......
Chromosomal Location1q42.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AGT collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting AGT.
ID Name Drug Type Targets #Targets
DB01593ZincSmall MoleculeA1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......119
DB09130CopperSmall MoleculeA1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......141
DB12548SparsentanSmall MoleculeAGT, EDNRA2