Browse ALOX15B

Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.; SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding.
Domain PF00305 Lipoxygenase
PF01477 PLAT/LH2 domain
Function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001676 long-chain fatty acid metabolic process
GO:0001819 positive regulation of cytokine production
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0008544 epidermis development
GO:0009306 protein secretion
GO:0009913 epidermal cell differentiation
GO:0010742 macrophage derived foam cell differentiation
GO:0010743 regulation of macrophage derived foam cell differentiation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016053 organic acid biosynthetic process
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0030850 prostate gland development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0032602 chemokine production
GO:0032642 regulation of chemokine production
GO:0032722 positive regulation of chemokine production
GO:0033559 unsaturated fatty acid metabolic process
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0040013 negative regulation of locomotion
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043588 skin development
GO:0043651 linoleic acid metabolic process
GO:0044283 small molecule biosynthetic process
GO:0045604 regulation of epidermal cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045682 regulation of epidermis development
GO:0045684 positive regulation of epidermis development
GO:0045786 negative regulation of cell cycle
GO:0045926 negative regulation of growth
GO:0046394 carboxylic acid biosynthetic process
GO:0048608 reproductive structure development
GO:0048732 gland development
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0051047 positive regulation of secretion
GO:0051121 hepoxilin metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0051222 positive regulation of protein transport
GO:0051271 negative regulation of cellular component movement
GO:0061458 reproductive system development
GO:0072330 monocarboxylic acid biosynthetic process
GO:0090077 foam cell differentiation
GO:0090195 chemokine secretion
GO:0090196 regulation of chemokine secretion
GO:0090197 positive regulation of chemokine secretion
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
GO:2000146 negative regulation of cell motility
Molecular Function GO:0005506 iron ion binding
GO:0016165 linoleate 13S-lipoxygenase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0036403 arachidonate 8(S)-lipoxygenase activity
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051213 dioxygenase activity
Cellular Component GO:0019898 extrinsic component of membrane
> KEGG and Reactome Pathway
 
KEGG hsa04726 Serotonergic synapse
hsa00590 Arachidonic acid metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-2142753: Arachidonic acid metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ALOX15B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ALOX15B and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
21900394renal cell carcinomaInhibit immunitywe show that TAMs isolated from human RCC produce substantial amounts of the proinflammatory chemokine CCL2 and immunosuppressive cytokine IL-10, in addition to enhanced eicosanoid production via an activated 15-lipoxygenase-2 (15-LOX2) pathway.
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ALOX15B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ALOX15B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2940.582
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6210.478
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.970.179
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2950.622
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6030.206
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3480.326
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.150.83
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6790.499
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5030.636
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0480.0535
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.350.0626
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2780.311
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ALOX15B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.57.43.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.57.15.41
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALOX15B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALOX15B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALOX15B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALOX15B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ALOX15B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ALOX15B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolALOX15B
Namearachidonate 15-lipoxygenase, type B
Aliases 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenas ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ALOX15B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.