Browse ATP5J

Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion. Mitochondrion inner membrane.
Domain PF05511 Mitochondrial ATP synthase coupling factor 6
Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

> Gene Ontology
 
Biological Process GO:0006164 purine nucleotide biosynthetic process
GO:0006754 ATP biosynthetic process
GO:0006818 hydrogen transport
GO:0006839 mitochondrial transport
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009124 nucleoside monophosphate biosynthetic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009127 purine nucleoside monophosphate biosynthetic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009145 purine nucleoside triphosphate biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009206 purine ribonucleoside triphosphate biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0015672 monovalent inorganic cation transport
GO:0015985 energy coupled proton transport, down electrochemical gradient
GO:0015986 ATP synthesis coupled proton transport
GO:0015992 proton transport
GO:0021762 substantia nigra development
GO:0030901 midbrain development
GO:0042278 purine nucleoside metabolic process
GO:0042451 purine nucleoside biosynthetic process
GO:0042455 ribonucleoside biosynthetic process
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046129 purine ribonucleoside biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0048857 neural nucleus development
GO:0072522 purine-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
GO:1902600 hydrogen ion transmembrane transport
GO:1990542 mitochondrial transmembrane transport
Molecular Function GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0016887 ATPase activity
Cellular Component GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0016469 proton-transporting two-sector ATPase complex
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0044455 mitochondrial membrane part
GO:0045259 proton-transporting ATP synthase complex
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
GO:0098798 mitochondrial protein complex
GO:0098800 inner mitochondrial membrane protein complex
> KEGG and Reactome Pathway
 
KEGG hsa00190 Oxidative phosphorylation
hsa01100 Metabolic pathways
Reactome R-HSA-163210: Formation of ATP by chemiosmotic coupling
R-HSA-1430728: Metabolism
R-HSA-163200: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP5J and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP5J in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.53 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP5J in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.160.483
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2080.948
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4240.86
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0980.76
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.080.949
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.320.829
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3140.441
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3230.863
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.30.885
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3970.874
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3610.926
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2270.00225
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATP5J in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP5J. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP5J. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP5J.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP5J. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP5J expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP5J and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP5J
NameATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Aliases CF6; coupling factor 6; ATP5; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; F6; ATPas ......
Chromosomal Location21q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP5J collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.