Browse B3GAT3

Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Single-pass type II membrane protein Golgi apparatus, cis-Golgi network
Domain PF03360 Glycosyltransferase family 43
Function

Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863).

> Gene Ontology
 
Biological Process GO:0006022 aminoglycan metabolic process
GO:0006023 aminoglycan biosynthetic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006029 proteoglycan metabolic process
GO:0006486 protein glycosylation
GO:0006790 sulfur compound metabolic process
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030166 proteoglycan biosynthetic process
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0043413 macromolecule glycosylation
GO:0044272 sulfur compound biosynthetic process
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process
GO:0050651 dermatan sulfate proteoglycan biosynthetic process
GO:0050654 chondroitin sulfate proteoglycan metabolic process
GO:0050655 dermatan sulfate proteoglycan metabolic process
GO:0051222 positive regulation of protein transport
GO:0070085 glycosylation
GO:0090316 positive regulation of intracellular protein transport
GO:1903510 mucopolysaccharide metabolic process
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0008047 enzyme activator activity
GO:0008194 UDP-glycosyltransferase activity
GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0015020 glucuronosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019208 phosphatase regulator activity
GO:0019211 phosphatase activator activity
GO:0019888 protein phosphatase regulator activity
GO:0072542 protein phosphatase activator activity
Cellular Component GO:0005801 cis-Golgi network
> KEGG and Reactome Pathway
 
KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100 Metabolic pathways
Reactome R-HSA-1971475: A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-1793185: Chondroitin sulfate/dermatan sulfate metabolism
R-HSA-1630316: Glycosaminoglycan metabolism
R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between B3GAT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of B3GAT3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.56 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of B3GAT3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.180.555
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.220.929
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1450.939
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4320.294
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3910.819
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4850.825
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0720.849
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1620.907
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0320.984
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.240.893
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1970.941
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0870.179
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of B3GAT3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of B3GAT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of B3GAT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by B3GAT3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of B3GAT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of B3GAT3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between B3GAT3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolB3GAT3
Namebeta-1,3-glucuronyltransferase 3
Aliases GlcAT-I; glucuronosyltransferase I; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; bet ......
Chromosomal Location11q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting B3GAT3 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting B3GAT3.
ID Name Drug Type Targets #Targets
DB03041UDP-alpha-D-glucuronic acidSmall MoleculeB3GAT3, GALE2
DB03435Uridine-5'-DiphosphateSmall MoleculeABO, B3GAT1, B3GAT3, CMPK1, EXTL2, GLT6D1, GYG17