| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | Cytoplasm Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein Endosome membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Mitochondrion membrane Peripheral membrane protein Endosome Cytoplasmic vesicle, autophagosome Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). ; SUBCELLULAR LOCATION: Beclin-1-C 35 kDa: Mitochondrion Nucleus Cytoplasm ; SUBCELLULAR LOCATION: Beclin-1-C 37 kDa: Mitochondrion |
| Domain |
PF04111 Autophagy protein Apg6 PF15285 Beclin-1 BH3 domain |
| Function |
Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. ; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. |
| Biological Process |
GO:0000045 autophagosome assembly GO:0000070 mitotic sister chromatid segregation GO:0000422 mitophagy GO:0000423 macromitophagy GO:0000819 sister chromatid segregation GO:0000910 cytokinesis GO:0001666 response to hypoxia GO:0006623 protein targeting to vacuole GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0006914 autophagy GO:0006968 cellular defense response GO:0006995 cellular response to nitrogen starvation GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0007040 lysosome organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007080 mitotic metaphase plate congression GO:0007088 regulation of mitotic nuclear division GO:0007346 regulation of mitotic cell cycle GO:0007584 response to nutrient GO:0008608 attachment of spindle microtubules to kinetochore GO:0009267 cellular response to starvation GO:0009615 response to virus GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010044 response to aluminum ion GO:0010324 membrane invagination GO:0010506 regulation of autophagy GO:0010508 positive regulation of autophagy GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0032258 CVT pathway GO:0032465 regulation of cytokinesis GO:0032801 receptor catabolic process GO:0033044 regulation of chromosome organization GO:0033045 regulation of sister chromatid segregation GO:0033047 regulation of mitotic sister chromatid segregation GO:0033197 response to vitamin E GO:0033273 response to vitamin GO:0036293 response to decreased oxygen levels GO:0042149 cellular response to glucose starvation GO:0042493 response to drug GO:0042594 response to starvation GO:0043112 receptor metabolic process GO:0043277 apoptotic cell clearance GO:0043562 cellular response to nitrogen levels GO:0043652 engulfment of apoptotic cell GO:0044804 nucleophagy GO:0045324 late endosome to vacuole transport GO:0045787 positive regulation of cell cycle GO:0045840 positive regulation of mitotic nuclear division GO:0045931 positive regulation of mitotic cell cycle GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0050000 chromosome localization GO:0050435 beta-amyloid metabolic process GO:0051302 regulation of cell division GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051315 attachment of mitotic spindle microtubules to kinetochore GO:0051607 defense response to virus GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0051983 regulation of chromosome segregation GO:0051984 positive regulation of chromosome segregation GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore GO:0051988 regulation of attachment of spindle microtubules to kinetochore GO:0061726 mitochondrion disassembly GO:0070482 response to oxygen levels GO:0070849 response to epidermal growth factor GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071275 cellular response to aluminum ion GO:0071364 cellular response to epidermal growth factor stimulus GO:0071496 cellular response to external stimulus GO:0072593 reactive oxygen species metabolic process GO:0072665 protein localization to vacuole GO:0072666 establishment of protein localization to vacuole GO:0080171 lytic vacuole organization GO:0090068 positive regulation of cell cycle process GO:0090235 regulation of metaphase plate congression GO:0098542 defense response to other organism GO:0098779 mitophagy in response to mitochondrial depolarization GO:0098780 response to mitochondrial depolarisation GO:0098813 nuclear chromosome segregation GO:0099024 plasma membrane invagination GO:1902423 regulation of mitotic attachment of spindle microtubules to kinetochore GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore GO:1903008 organelle disassembly GO:1903146 regulation of mitophagy GO:1903599 positive regulation of mitophagy GO:1905037 autophagosome organization GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2001252 positive regulation of chromosome organization |
| Molecular Function |
GO:0031625 ubiquitin protein ligase binding GO:0043548 phosphatidylinositol 3-kinase binding GO:0044389 ubiquitin-like protein ligase binding |
| Cellular Component |
GO:0000407 pre-autophagosomal structure GO:0005776 autophagosome GO:0005802 trans-Golgi network GO:0005942 phosphatidylinositol 3-kinase complex GO:0010008 endosome membrane GO:0019898 extrinsic component of membrane GO:0030139 endocytic vesicle GO:0030425 dendrite GO:0031984 organelle subcompartment GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II GO:0035032 phosphatidylinositol 3-kinase complex, class III GO:0044440 endosomal part GO:0045335 phagocytic vesicle GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0098791 Golgi subcompartment |
| KEGG |
hsa04140 Regulation of autophagy |
| Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-5688426: Deubiquitination R-HSA-1632852: Macroautophagy R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-5689880: Ub-specific processing proteases |
| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between BECN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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Literatures describing the relation between BECN1 and anti-tumor immunity in human cancer.
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| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of BECN1 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of BECN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BECN1 in various data sets.
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| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BECN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BECN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BECN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BECN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of BECN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between BECN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | BECN1 |
| Name | beclin 1, autophagy related |
| Aliases | ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ...... |
| Chromosomal Location | 17q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting BECN1 collected from DrugBank database. |
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Details on drugs targeting BECN1.
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