Browse BEST3

Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF01062 Bestrophin
Function

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

> Gene Ontology
 
Biological Process GO:0006820 anion transport
GO:0006821 chloride transport
GO:0015698 inorganic anion transport
GO:0043271 negative regulation of ion transport
GO:0051051 negative regulation of transport
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1902476 chloride transmembrane transport
Molecular Function GO:0005216 ion channel activity
GO:0005253 anion channel activity
GO:0005254 chloride channel activity
GO:0008509 anion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
Cellular Component GO:0034702 ion channel complex
GO:0034707 chloride channel complex
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-983712: Ion channel transport
R-HSA-2672351: Stimuli-sensing channels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BEST3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BEST3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BEST3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1310.51
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.330.521
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0140.974
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6940.263
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8850.502
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.460.752
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0770.897
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1070.894
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.7720.0138
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BEST3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21171911.87.20.672
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.57.43.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.215.42.81
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BEST3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BEST3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BEST3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BEST3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BEST3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BEST3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBEST3
Namebestrophin 3
Aliases MGC40411; MGC13168; VMD2L3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like pro ......
Chromosomal Location12q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BEST3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.