TISIDB

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Golgi apparatus.
Domain	PF09730 Microtubule-associated protein Bicaudal-D
Function	Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0006403 RNA localization GO:0006898 receptor-mediated endocytosis GO:0007018 microtubule-based movement GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0008298 intracellular mRNA localization GO:0010469 regulation of receptor activity GO:0010517 regulation of phospholipase activity GO:0010519 negative regulation of phospholipase activity GO:0010970 transport along microtubule GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0030100 regulation of endocytosis GO:0030705 cytoskeleton-dependent intracellular transport GO:0034063 stress granule assembly GO:0034453 microtubule anchoring GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045807 positive regulation of endocytosis GO:0048259 regulation of receptor-mediated endocytosis GO:0048260 positive regulation of receptor-mediated endocytosis GO:0051346 negative regulation of hydrolase activity GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0060191 regulation of lipase activity GO:0060192 negative regulation of lipase activity GO:0060627 regulation of vesicle-mediated transport GO:0071826 ribonucleoprotein complex subunit organization GO:0072384 organelle transport along microtubule GO:0072385 minus-end-directed organelle transport along microtubule GO:0072393 microtubule anchoring at microtubule organizing center GO:1900274 regulation of phospholipase C activity GO:1900275 negative regulation of phospholipase C activity GO:1900276 regulation of proteinase activated receptor activity GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900737 negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
Molecular Function	GO:0001664 G-protein coupled receptor binding GO:0005200 structural constituent of cytoskeleton GO:0008093 cytoskeletal adaptor activity GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0030674 protein binding, bridging GO:0031267 small GTPase binding GO:0031871 proteinase activated receptor binding GO:0034452 dynactin binding GO:0045502 dynein binding GO:0051020 GTPase binding GO:0060090 binding, bridging
Cellular Component	GO:0005802 trans-Golgi network GO:0005874 microtubule GO:0005881 cytoplasmic microtubule GO:0018995 host GO:0030430 host cell cytoplasm GO:0031984 organelle subcompartment GO:0033643 host cell part GO:0033646 host intracellular part GO:0033647 host intracellular organelle GO:0033648 host intracellular membrane-bounded organelle GO:0033655 host cell cytoplasm part GO:0039713 viral factory GO:0039714 cytoplasmic viral factory GO:0043656 intracellular region of host GO:0043657 host cell GO:0044215 other organism GO:0044216 other organism cell GO:0044217 other organism part GO:0045298 tubulin complex GO:0072517 host cell viral assembly compartment GO:0098791 Golgi subcompartment

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-6811436: COPI-independent Golgi-to-ER retrograde traffic R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between BICD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of BICD1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of BICD1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.094	0.784
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.591	0.576
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.263	0.719
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.055	0.817
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.074	0.968
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.028	0.991
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.031	0.934
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.118	0.924
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.316	0.796
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.16	0.899
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.099	0.957
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.248	0.0224

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of BICD1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	1.4	13.4	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	1.7	13.1	0.032
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BICD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BICD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BICD1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BICD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of BICD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between BICD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	BICD1
Name	bicaudal D homolog 1 (Drosophila)
Aliases	Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location	12p11.2-p11.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting BICD1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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