Browse CARD11

Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Membrane raft Note=Colocalized with DPP4 in membrane rafts.
Domain PF00619 Caspase recruitment domain
Function

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.

> Gene Ontology
 
Biological Process GO:0001819 positive regulation of cytokine production
GO:0002218 activation of innate immune response
GO:0002220 innate immune response activating cell surface receptor signaling pathway
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002521 leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0007159 leukocyte cell-cell adhesion
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030888 regulation of B cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031349 positive regulation of defense response
GO:0032623 interleukin-2 production
GO:0032663 regulation of interleukin-2 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033077 T cell differentiation in thymus
GO:0038093 Fc receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042035 regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042094 interleukin-2 biosynthetic process
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042107 cytokine metabolic process
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042129 regulation of T cell proliferation
GO:0042278 purine nucleoside metabolic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045058 T cell selection
GO:0045061 thymic T cell selection
GO:0045076 regulation of interleukin-2 biosynthetic process
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045577 regulation of B cell differentiation
GO:0045580 regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045785 positive regulation of cell adhesion
GO:0046037 GMP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046651 lymphocyte proliferation
GO:0046710 GDP metabolic process
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:1901068 guanosine-containing compound metabolic process
GO:1901657 glycosyl compound metabolic process
GO:1902105 regulation of leukocyte differentiation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903706 regulation of hemopoiesis
Molecular Function GO:0004385 guanylate kinase activity
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019201 nucleotide kinase activity
GO:0019205 nucleobase-containing compound kinase activity
GO:0050700 CARD domain binding
Cellular Component GO:0001772 immunological synapse
GO:0042101 T cell receptor complex
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0098589 membrane region
GO:0098802 plasma membrane receptor complex
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04064 NF-kappa B signaling pathway
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
Reactome R-HSA-1169091: Activation of NF-kappaB in B cells
R-HSA-1280218: Adaptive Immune System
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-202424: Downstream TCR signaling
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2871837: FCERI mediated NF-kB activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-202403: TCR signaling
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CARD11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CARD11 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
19815501MelanomaPromote immunity (T cell function)CARMA1(-/-) NKT cells are defective in IFN-gamma production.
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CARD11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CARD11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2430.58
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6420.392
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0560.934
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1490.791
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2380.906
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0330.989
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4550.367
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.610.511
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2510.809
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.7330.114
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6650.29
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4350.0259
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CARD11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CARD11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CARD11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CARD11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CARD11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CARD11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CARD11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCARD11
Namecaspase recruitment domain family, member 11
Aliases CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CARD11 collected from DrugBank database.
> Drugs from DrugBank database
 

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