TISIDB

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm. Nucleus.
Domain	PF02234 Cyclin-dependent kinase inhibitor
Function	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).

> Gene Ontology [ TOP ]
Biological Process	GO:0000060 protein import into nucleus, translocation GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle GO:0000086 G2/M transition of mitotic cell cycle GO:0001558 regulation of cell growth GO:0001933 negative regulation of protein phosphorylation GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0002069 columnar/cuboidal epithelial cell maturation GO:0002070 epithelial cell maturation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0006469 negative regulation of protein kinase activity GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007265 Ras protein signal transduction GO:0007346 regulation of mitotic cell cycle GO:0007568 aging GO:0007569 cell aging GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009266 response to temperature stimulus GO:0009267 cellular response to starvation GO:0009314 response to radiation GO:0009408 response to heat GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009636 response to toxic substance GO:0009991 response to extracellular stimulus GO:0010165 response to X-ray GO:0010212 response to ionizing radiation GO:0010224 response to UV-B GO:0010948 negative regulation of cell cycle process GO:0016049 cell growth GO:0017038 protein import GO:0021700 developmental maturation GO:0030308 negative regulation of cell growth GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031647 regulation of protein stability GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031960 response to corticosteroid GO:0032386 regulation of intracellular transport GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033158 regulation of protein import into nucleus, translocation GO:0033673 negative regulation of kinase activity GO:0033674 positive regulation of kinase activity GO:0034198 cellular response to amino acid starvation GO:0034504 protein localization to nucleus GO:0034605 cellular response to heat GO:0034644 cellular response to UV GO:0036296 response to increased oxygen levels GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0042306 regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042493 response to drug GO:0042594 response to starvation GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0044744 protein targeting to nucleus GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044839 cell cycle G2/M phase transition GO:0044843 cell cycle G1/S phase transition GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0045926 negative regulation of growth GO:0045930 negative regulation of mitotic cell cycle GO:0046651 lymphocyte proliferation GO:0046685 response to arsenic-containing substance GO:0046822 regulation of nucleocytoplasmic transport GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048469 cell maturation GO:0048545 response to steroid hormone GO:0048565 digestive tract development GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050821 protein stabilization GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0051052 regulation of DNA metabolic process GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051348 negative regulation of transferase activity GO:0051384 response to glucocorticoid GO:0051385 response to mineralocorticoid GO:0051412 response to corticosterone GO:0055093 response to hyperoxia GO:0055123 digestive system development GO:0060574 intestinal epithelial cell maturation GO:0060575 intestinal epithelial cell differentiation GO:0060576 intestinal epithelial cell development GO:0070482 response to oxygen levels GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071482 cellular response to light stimulus GO:0071493 cellular response to UV-B GO:0071496 cellular response to external stimulus GO:0071850 mitotic cell cycle arrest GO:0071897 DNA biosynthetic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0072593 reactive oxygen species metabolic process GO:0090068 positive regulation of cell cycle process GO:0090398 cellular senescence GO:0090399 replicative senescence GO:0090400 stress-induced premature senescence GO:0097193 intrinsic apoptotic signaling pathway GO:1900180 regulation of protein localization to nucleus GO:1901654 response to ketone GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902593 single-organism nuclear import GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903533 regulation of protein targeting GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904030 negative regulation of cyclin-dependent protein kinase activity GO:1904031 positive regulation of cyclin-dependent protein kinase activity GO:1904589 regulation of protein import GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000278 regulation of DNA biosynthetic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process
Molecular Function	GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0008047 enzyme activator activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019210 kinase inhibitor activity GO:0019887 protein kinase regulator activity GO:0019912 cyclin-dependent protein kinase activating kinase activity GO:0030291 protein serine/threonine kinase inhibitor activity GO:0030295 protein kinase activator activity GO:0030332 cyclin binding GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding
Cellular Component	GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0070557 PCNA-p21 complex GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04012 ErbB signaling pathway hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04630 Jak-STAT signaling pathway hsa04921 Oxytocin signaling pathway
Reactome	R-HSA-198323: AKT phosphorylates targets in the cytosol R-HSA-1280218: Adaptive Immune System R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer R-HSA-69656: Cyclin A R-HSA-69231: Cyclin D associated events in G1 R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-69306: DNA Replication R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-69236: G1 Phase R-HSA-69615: G1/S DNA Damage Checkpoints R-HSA-69206: G1/S Transition R-HSA-69275: G2/M Transition R-HSA-180292: GAB1 signalosome R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-453279: Mitotic G1-G1/S phases R-HSA-453274: Mitotic G2-G2/M phases R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-68949: Orc1 removal from chromatin R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-1257604: PIP3 activates AKT signaling R-HSA-69304: Regulation of DNA replication R-HSA-69300: Removal of licensing factors from origins R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-69242: S Phase R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-449147: Signaling by Interleukins R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-69052: Switching of origins to a post-replicative state R-HSA-69239: Synthesis of DNA R-HSA-8866911: TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804116: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-69895: Transcriptional activation of cell cycle inhibitor p21 R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-69560: Transcriptional activation of p53 responsive genes R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-69563: p53-Dependent G1 DNA Damage Response R-HSA-69580: p53-Dependent G1/S DNA damage checkpoint

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04012 ErbB signaling pathway
hsa04066 HIF-1 signaling pathway
hsa04068 FoxO signaling pathway
hsa04110 Cell cycle
hsa04115 p53 signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04921 Oxytocin signaling pathway

Reactome

R-HSA-198323: AKT phosphorylates targets in the cytosol
R-HSA-1280218: Adaptive Immune System
R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-69656: Cyclin A
R-HSA-69231: Cyclin D associated events in G1
R-HSA-69202: Cyclin E associated events during G1/S transition
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence
R-HSA-69306: DNA Replication
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-69236: G1 Phase
R-HSA-69615: G1/S DNA Damage Checkpoints
R-HSA-69206: G1/S Transition
R-HSA-69275: G2/M Transition
R-HSA-180292: GAB1 signalosome
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-68949: Orc1 removal from chromatin
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-69304: Regulation of DNA replication
R-HSA-69300: Removal of licensing factors from origins
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-69242: S Phase
R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP)
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-449147: Signaling by Interleukins
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-69052: Switching of origins to a post-replicative state
R-HSA-69239: Synthesis of DNA
R-HSA-8866911: TFAP2 (AP-2) family regulates transcription of cell cycle factors
R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804116: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-69895: Transcriptional activation of cell cycle inhibitor p21
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-69560: Transcriptional activation of p53 responsive genes
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-69563: p53-Dependent G1 DNA Damage Response
R-HSA-69580: p53-Dependent G1/S DNA damage checkpoint

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CDKN1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between CDKN1A and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
19276356	Breast carcinoma	Promote immunity	p21 loss has been implicated in conferring oncogenic activity to known tumor suppressor gene KLF4 and cancer drug tamoxifen. Regulators of p21, therefore, play critical roles in tumorigenesis.
29774202	Large Cell Lung Carcinoma	Promote immunity	Loss of the Cyclin-Dependent Kinase Inhibitor 1 in the Context of Brachyury-Mediated Phenotypic Plasticity Drives Tumor Resistance to Immune Attack. Our results demonstrate that very high levels of brachyury expression drive the loss of the cyclin-dependent kinase inhibitor 1 (p21CIP1, p21), an event that results in decreased tumor susceptibility to immune-mediated lysis.

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of CDKN1A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: 1.38; FDR: 0.000150	Sensitive to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of CDKN1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.331	0.437
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.03	0.991
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.589	0.781
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.011	0.981
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.228	0.915
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.316	0.904
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.052	0.926
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.509	0.772
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.651	0.742
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.386	0.848
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.055	0.717
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.328	0.00743

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of CDKN1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	1

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDKN1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDKN1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDKN1A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDKN1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CDKN1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CDKN1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

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Summary
Symbol	CDKN1A
Name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases	WAF1; SDI1; CAP20; p21CIP1; p21Cip1/Waf1; CDKN1; MDA-6; CDK-interacting protein 1; CDK-interaction protein 1 ......
Chromosomal Location	6p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CDKN1A collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting CDKN1A.

ID	Name	Drug Type	Targets	#Targets
DB01169	Arsenic trioxide	Small Molecule	AKT1, CCND1, CDKN1A, HDAC1, IKBKB, JUN, MAPK1, MAPK3, PML, TXNRD1	10

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