Browse CDON

Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass membrane protein
Domain PF00041 Fibronectin type III domain
PF07679 Immunoglobulin I-set domain
Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

> Gene Ontology
 
Biological Process GO:0000768 syncytium formation by plasma membrane fusion
GO:0001654 eye development
GO:0001708 cell fate specification
GO:0002088 lens development in camera-type eye
GO:0003002 regionalization
GO:0006949 syncytium formation
GO:0007224 smoothened signaling pathway
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007520 myoblast fusion
GO:0009952 anterior/posterior pattern specification
GO:0010171 body morphogenesis
GO:0010172 embryonic body morphogenesis
GO:0010720 positive regulation of cell development
GO:0014706 striated muscle tissue development
GO:0014816 skeletal muscle satellite cell differentiation
GO:0014902 myotube differentiation
GO:0016202 regulation of striated muscle tissue development
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021987 cerebral cortex development
GO:0030900 forebrain development
GO:0035914 skeletal muscle cell differentiation
GO:0042692 muscle cell differentiation
GO:0043010 camera-type eye development
GO:0043393 regulation of protein binding
GO:0043410 positive regulation of MAPK cascade
GO:0043497 regulation of protein heterodimerization activity
GO:0045165 cell fate commitment
GO:0045445 myoblast differentiation
GO:0045661 regulation of myoblast differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045844 positive regulation of striated muscle tissue development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0050769 positive regulation of neurogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051098 regulation of binding
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051962 positive regulation of nervous system development
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0061351 neural precursor cell proliferation
GO:0090596 sensory organ morphogenesis
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04340 Hedgehog signaling pathway
Reactome R-HSA-5635838: Activation of SMO
R-HSA-375170: CDO in myogenesis
R-HSA-1266738: Developmental Biology
R-HSA-5632684: Hedgehog 'on' state
R-HSA-5632681: Ligand-receptor interactions
R-HSA-525793: Myogenesis
R-HSA-162582: Signal Transduction
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CDON and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CDON in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CDON in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1390.649
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0170.981
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2190.744
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3610.438
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2040.901
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5640.768
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1020.775
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3660.781
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2620.849
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.7190.512
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0470.973
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0620.774
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CDON in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.81.413.40.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.81.713.10.032
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CDON. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CDON. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CDON.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CDON. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CDON expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CDON and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCDON
Namecell adhesion associated, oncogene regulated
Aliases ORCAM; CDON1; cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog (mouse); HPE11; Cdon ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CDON collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.