Browse CLIC6

Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell membrane Single-pass membrane protein Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity).
Domain -
Function

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).

> Gene Ontology
 
Biological Process GO:0006820 anion transport
GO:0006821 chloride transport
GO:0015698 inorganic anion transport
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1902476 chloride transmembrane transport
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005253 anion channel activity
GO:0005254 chloride channel activity
GO:0008509 anion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0050780 dopamine receptor binding
Cellular Component GO:0034702 ion channel complex
GO:0034707 chloride channel complex
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CLIC6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CLIC6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CLIC6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0160.0129
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.010.00318
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.290.642
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8190.197
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1030.95
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.7130.333
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4880.513
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.0380.349
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0050.997
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.340.187
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.5130.0492
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0860.781
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CLIC6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CLIC6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CLIC6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CLIC6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CLIC6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CLIC6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CLIC6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCLIC6
Namechloride intracellular channel 6
Aliases CLIC1L; chloride channel form A; parchorin; Chloride intracellular channel protein 6
Chromosomal Location21q22.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CLIC6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.