TISIDB

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane.
Domain	PF00386 C1q domain PF01391 Collagen triple helix repeat (20 copies)
Function	Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. ; FUNCTION: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.

> Gene Ontology [ TOP ]
Biological Process	GO:0001525 angiogenesis GO:0001654 eye development GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0007369 gastrulation GO:0007423 sensory organ development GO:0007492 endoderm development GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0030198 extracellular matrix organization GO:0030574 collagen catabolic process GO:0031589 cell-substrate adhesion GO:0032963 collagen metabolic process GO:0035987 endodermal cell differentiation GO:0043010 camera-type eye development GO:0043062 extracellular structure organization GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045785 positive regulation of cell adhesion GO:0048514 blood vessel morphogenesis GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0050673 epithelial cell proliferation GO:0090596 sensory organ morphogenesis
Molecular Function	-
Cellular Component	GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005591 collagen type VIII trimer GO:0005598 short-chain collagen trimer GO:0005604 basement membrane GO:0005788 endoplasmic reticulum lumen GO:0030935 sheet-forming collagen trimer GO:0044420 extracellular matrix component GO:0098642 network-forming collagen trimer GO:0098644 complex of collagen trimers GO:0098645 collagen network GO:0098646 collagen sheet GO:0098651 basement membrane collagen trimer

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between COL8A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of COL8A1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of COL8A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.829	0.00854
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-2.211	0.118
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1.547	0.169
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.576	0.174
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.721	0.739
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.391	0.888
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.326	0.615
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.114	0.923
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.584	0.645
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.874	0.371
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	3.622	0.192
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.39	0.0779

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of COL8A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	5.5	1.9	0.66
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	5.1	2.3	0.647
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL8A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL8A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL8A1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL8A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of COL8A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between COL8A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	COL8A1
Name	collagen, type VIII, alpha 1
Aliases	MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location	3q11.1-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting COL8A1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse COL8A1