Browse CPN1

Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space.
Domain PF00246 Zinc carboxypeptidase
Function

Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.

> Gene Ontology
 
Biological Process GO:0010815 bradykinin catabolic process
GO:0016485 protein processing
GO:0031960 response to corticosteroid
GO:0043171 peptide catabolic process
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
GO:0051604 protein maturation
GO:1901565 organonitrogen compound catabolic process
Molecular Function GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0008237 metallopeptidase activity
GO:0008238 exopeptidase activity
GO:0017171 serine hydrolase activity
GO:0070008 serine-type exopeptidase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-264876: Insulin processing
R-HSA-392499: Metabolism of proteins
R-HSA-2980736: Peptide hormone metabolism
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CPN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CPN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CPN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.3290.0477
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7940.546
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.7190.104
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9220.359
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.070.442
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.7580.674
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.0770.36
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.920.575
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.9670.593
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5940.544
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0880.945
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0310.896
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CPN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CPN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CPN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CPN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CPN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CPN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CPN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCPN1
Namecarboxypeptidase N, polypeptide 1
Aliases anaphylatoxin inactivator; carboxypeptidase K; kininase I; lysine carboxypeptidase; carboxypeptidase N, poly ......
Chromosomal Location10q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CPN1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CPN1.
ID Name Drug Type Targets #Targets
DB01593ZincSmall MoleculeA1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......119