TISIDB

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Desert hedgehog protein N-product: Cell membrane Lipid-anchor Extracellular side Note=The N-terminal peptide remains associated with the cell surface. ; SUBCELLULAR LOCATION: Desert hedgehog protein C-product: Secreted, extracellular space Note=The C-terminal peptide diffuses from the cell.
Domain	PF01085 Hedgehog amino-terminal signalling domain PF01079 Hint module
Function	Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.

> Gene Ontology [ TOP ]
Biological Process	GO:0006694 steroid biosynthetic process GO:0007272 ensheathment of neurons GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007530 sex determination GO:0007548 sex differentiation GO:0008202 steroid metabolic process GO:0008366 axon ensheathment GO:0008406 gonad development GO:0008584 male gonad development GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030238 male sex determination GO:0032355 response to estradiol GO:0033327 Leydig cell differentiation GO:0042552 myelination GO:0043627 response to estrogen GO:0045137 development of primary sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0046890 regulation of lipid biosynthetic process GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0048608 reproductive structure development GO:0050810 regulation of steroid biosynthetic process GO:0061458 reproductive system development
Molecular Function	GO:0005113 patched binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04340 Hedgehog signaling pathway
Reactome	R-HSA-5635838: Activation of SMO R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-500792: GPCR ligand binding R-HSA-5658034: HHAT G278V abrogates palmitoylation of Hh-Np R-HSA-5632684: Hedgehog 'on' state R-HSA-5358346: Hedgehog ligand biogenesis R-HSA-5387390: Hh mutants abrogate ligand secretion R-HSA-5632681: Ligand-receptor interactions R-HSA-5362798: Release of Hh-Np from the secreting cell R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-5358351: Signaling by Hedgehog

> KEGG and Reactome Pathway

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KEGG

hsa04340 Hedgehog signaling pathway

Reactome

R-HSA-5635838: Activation of SMO
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-500792: GPCR ligand binding
R-HSA-5658034: HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-5632684: Hedgehog 'on' state
R-HSA-5358346: Hedgehog ligand biogenesis
R-HSA-5387390: Hh mutants abrogate ligand secretion
R-HSA-5632681: Ligand-receptor interactions
R-HSA-5362798: Release of Hh-Np from the secreting cell
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DHH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of DHH in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.53	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of DHH in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.508	0.333
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.349	0.687
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.62	0.393
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.425	0.539
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.157	0.884
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.767	0.529
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	0.999
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.446	0.661
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.562	0.62
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.08	0.84
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.125	0.825
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.178	0.328

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of DHH in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	2.7	-2.7	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	3.4	-3.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	16.7	-16.7	0.429
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DHH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DHH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DHH. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DHH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DHH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DHH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DHH
Name	desert hedgehog
Aliases	HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location	12q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DHH collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse DHH