Browse EPHB6

Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Secreted
Domain PF14575 Ephrin type-A receptor 2 transmembrane domain
PF01404 Ephrin receptor ligand binding domain
PF07699 Putative ephrin-receptor like
PF00041 Fibronectin type III domain
PF07714 Protein tyrosine kinase
PF07647 SAM domain (Sterile alpha motif)
Function

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

> Gene Ontology
 
Biological Process GO:0048013 ephrin receptor signaling pathway
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0019199 transmembrane receptor protein kinase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
Reactome R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928665: EPH-ephrin mediated repulsion of cells
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-3928664: Ephrin signaling
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between EPHB6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of EPHB6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of EPHB6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1750.677
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.180.81
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1810.757
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2580.648
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2420.91
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2720.916
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.8890.162
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.230.208
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4930.643
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.2850.311
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.1710.207
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8230.00124
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of EPHB6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.49.6-2.21
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.411.9-4.50.713
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EPHB6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EPHB6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EPHB6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EPHB6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of EPHB6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between EPHB6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolEPHB6
NameEPH receptor B6
Aliases human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6; Ephrin ......
Chromosomal Location7q33-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting EPHB6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.