Browse ESPL1

Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus.
Domain -
Function

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000819 sister chromatid segregation
GO:0000910 cytokinesis
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007063 regulation of sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007346 regulation of mitotic cell cycle
GO:0010639 negative regulation of organelle organization
GO:0010948 negative regulation of cell cycle process
GO:0010965 regulation of mitotic sister chromatid separation
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0033044 regulation of chromosome organization
GO:0033045 regulation of sister chromatid segregation
GO:0033046 negative regulation of sister chromatid segregation
GO:0033047 regulation of mitotic sister chromatid segregation
GO:0040001 establishment of mitotic spindle localization
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044784 metaphase/anaphase transition of cell cycle
GO:0045132 meiotic chromosome segregation
GO:0045143 homologous chromosome segregation
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045840 positive regulation of mitotic nuclear division
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0045875 negative regulation of sister chromatid cohesion
GO:0045931 positive regulation of mitotic cell cycle
GO:0051293 establishment of spindle localization
GO:0051304 chromosome separation
GO:0051306 mitotic sister chromatid separation
GO:0051307 meiotic chromosome separation
GO:0051321 meiotic cell cycle
GO:0051640 organelle localization
GO:0051653 spindle localization
GO:0051656 establishment of organelle localization
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0051983 regulation of chromosome segregation
GO:0051984 positive regulation of chromosome segregation
GO:0051985 negative regulation of chromosome segregation
GO:0090068 positive regulation of cell cycle process
GO:0098813 nuclear chromosome segregation
GO:1901970 positive regulation of mitotic sister chromatid separation
GO:1901987 regulation of cell cycle phase transition
GO:1901989 positive regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901992 positive regulation of mitotic cell cycle phase transition
GO:1902099 regulation of metaphase/anaphase transition of cell cycle
GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle
GO:1903046 meiotic cell cycle process
GO:2001251 negative regulation of chromosome organization
GO:2001252 positive regulation of chromosome organization
Molecular Function GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Cellular Component GO:0005813 centrosome
GO:0005819 spindle
GO:0072686 mitotic spindle
> KEGG and Reactome Pathway
 
KEGG hsa04110 Cell cycle
hsa04114 Oocyte meiosis
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-68886: M Phase
R-HSA-68882: Mitotic Anaphase
R-HSA-2555396: Mitotic Metaphase and Anaphase
R-HSA-2467813: Separation of Sister Chromatids
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ESPL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ESPL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ESPL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0810.778
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0080.993
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1490.836
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5490.241
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5510.762
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5520.82
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0130.974
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4490.712
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.610.602
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6640.338
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5170.607
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6424.36e-07
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ESPL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.37.4-2.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ESPL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ESPL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ESPL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ESPL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ESPL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ESPL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolESPL1
Nameextra spindle pole bodies like 1, separase
Aliases KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ......
Chromosomal Location12q13.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ESPL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.