TISIDB

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Endomembrane system Single-pass membrane protein Cytoplasm, cytoskeleton Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
Domain	PF01425 Amidase
Function	Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

> Gene Ontology [ TOP ]
Biological Process	GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006690 icosanoid metabolic process GO:0009062 fatty acid catabolic process GO:0016042 lipid catabolic process GO:0016054 organic acid catabolic process GO:0019369 arachidonic acid metabolic process GO:0033559 unsaturated fatty acid metabolic process GO:0044242 cellular lipid catabolic process GO:0044282 small molecule catabolic process GO:0046395 carboxylic acid catabolic process GO:0072329 monocarboxylic acid catabolic process
Molecular Function	GO:0016298 lipase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0017064 fatty acid amide hydrolase activity GO:0047372 acylglycerol lipase activity GO:0052689 carboxylic ester hydrolase activity GO:0103073 anandamide amidohydrolase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04723 Retrograde endocannabinoid signaling
Reactome	R-HSA-2142753: Arachidonic acid metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FAAH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of FAAH in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FAAH in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.652	0.105
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.25	0.754
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.949	0.122
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.884	0.0474
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.85	0.649
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.926	0.687
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.077	0.842
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.631	0.369
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.861	0.253
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.143	0.918
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.276	0.883
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.063	0.665

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of FAAH in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	1.4	6	0.177
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	1.7	5.7	0.231
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAAH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAAH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAAH. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAAH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FAAH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FAAH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FAAH
Name	fatty acid amide hydrolase
Aliases	FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1
Chromosomal Location	1p35-p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FAAH collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting FAAH.

ID	Name	Drug Type	Targets	#Targets
DB00316	Acetaminophen	Small Molecule	FAAH, GSTP1, PTGS1, PTGS2, TRPV1	5
DB00599	Thiopental	Small Molecule	CHRM3, CHRNA4, CHRNA7, FAAH, GABRA1, GABRA2, GABRA3, GABRA4, GABRA ......	12
DB02465	Methoxy arachidonyl fluorophosphonate	Small Molecule	FAAH	1
DB06894	1-DODECANOL	Small Molecule	FAAH	1
DB08385	4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid	Small Molecule	FAAH	1
DB08400	4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid	Small Molecule	FAAH	1

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