TISIDB

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Domain	PF00167 Fibroblast growth factor
Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

> Gene Ontology [ TOP ]
Biological Process	GO:0000187 activation of MAPK activity GO:0001525 angiogenesis GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001667 ameboidal-type cell migration GO:0001759 organ induction GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0002040 sprouting angiogenesis GO:0003002 regionalization GO:0003156 regulation of animal organ formation GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0003401 axis elongation GO:0006066 alcohol metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0007389 pattern specification process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008654 phospholipid biosynthetic process GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0010092 specification of animal organ identity GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010893 positive regulation of steroid biosynthetic process GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0016125 sterol metabolic process GO:0016126 sterol biosynthetic process GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0030258 lipid modification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0031128 developmental induction GO:0032147 activation of protein kinase activity GO:0032148 activation of protein kinase B activity GO:0033674 positive regulation of kinase activity GO:0034605 cellular response to heat GO:0035239 tube morphogenesis GO:0035766 cell chemotaxis to fibroblast growth factor GO:0035767 endothelial cell chemotaxis GO:0035768 endothelial cell chemotaxis to fibroblast growth factor GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0040017 positive regulation of locomotion GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043542 endothelial cell migration GO:0044283 small molecule biosynthetic process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045017 glycerolipid biosynthetic process GO:0045540 regulation of cholesterol biosynthetic process GO:0045542 positive regulation of cholesterol biosynthetic process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045834 positive regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0045940 positive regulation of steroid metabolic process GO:0046165 alcohol biosynthetic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048514 blood vessel morphogenesis GO:0048645 animal organ formation GO:0048754 branching morphogenesis of an epithelial tube GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050810 regulation of steroid biosynthetic process GO:0050920 regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0051302 regulation of cell division GO:0051781 positive regulation of cell division GO:0060326 cell chemotaxis GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060602 branch elongation of an epithelium GO:0060675 ureteric bud morphogenesis GO:0060677 ureteric bud elongation GO:0060681 branch elongation involved in ureteric bud branching GO:0060993 kidney morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061154 endothelial tube morphogenesis GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071774 response to fibroblast growth factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090181 regulation of cholesterol metabolic process GO:0090205 positive regulation of cholesterol metabolic process GO:0090287 regulation of cellular response to growth factor stimulus GO:1901342 regulation of vasculature development GO:1901509 regulation of endothelial tube morphogenesis GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902652 secondary alcohol metabolic process GO:1902653 secondary alcohol biosynthetic process GO:1902930 regulation of alcohol biosynthetic process GO:1902932 positive regulation of alcohol biosynthetic process GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:1904847 regulation of cell chemotaxis to fibroblast growth factor GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2001026 regulation of endothelial cell chemotaxis
Molecular Function	GO:0004713 protein tyrosine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005104 fibroblast growth factor receptor binding GO:0005178 integrin binding GO:0005539 glycosaminoglycan binding GO:0008083 growth factor activity GO:0008201 heparin binding GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0030544 Hsp70 protein binding GO:0031072 heat shock protein binding GO:0035004 phosphatidylinositol 3-kinase activity GO:0044548 S100 protein binding GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0050839 cell adhesion molecule binding GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:0070851 growth factor receptor binding GO:1901681 sulfur compound binding
Cellular Component	GO:0005578 proteinaceous extracellular matrix GO:0005938 cell cortex GO:0099568 cytoplasmic region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04390 Hippo signaling pathway hsa04810 Regulation of actin cytoskeleton
Reactome	R-HSA-170984: ARMS-mediated activation R-HSA-2033519: Activated point mutants of FGFR2 R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-5654687: Downstream signaling of activated FGFR1 R-HSA-5654696: Downstream signaling of activated FGFR2 R-HSA-5654708: Downstream signaling of activated FGFR3 R-HSA-5654716: Downstream signaling of activated FGFR4 R-HSA-2871796: FCERI mediated MAPK activation R-HSA-190242: FGFR1 ligand binding and activation R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-190370: FGFR1b ligand binding and activation R-HSA-190373: FGFR1c ligand binding and activation R-HSA-190241: FGFR2 ligand binding and activation R-HSA-1839126: FGFR2 mutant receptor activation R-HSA-190377: FGFR2b ligand binding and activation R-HSA-190375: FGFR2c ligand binding and activation R-HSA-190239: FGFR3 ligand binding and activation R-HSA-2033514: FGFR3 mutant receptor activation R-HSA-190371: FGFR3b ligand binding and activation R-HSA-190372: FGFR3c ligand binding and activation R-HSA-190322: FGFR4 ligand binding and activation R-HSA-5654693: FRS-mediated FGFR1 signaling R-HSA-5654700: FRS-mediated FGFR2 signaling R-HSA-5654706: FRS-mediated FGFR3 signaling R-HSA-5654712: FRS-mediated FGFR4 signaling R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5654726: Negative regulation of FGFR1 signaling R-HSA-5654727: Negative regulation of FGFR2 signaling R-HSA-5654732: Negative regulation of FGFR3 signaling R-HSA-5654733: Negative regulation of FGFR4 signaling R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-5654689: PI-3K cascade R-HSA-5654695: PI-3K cascade R-HSA-5654710: PI-3K cascade R-HSA-5654720: PI-3K cascade R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-5654219: Phospholipase C-mediated cascade R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2 R-HSA-5654227: Phospholipase C-mediated cascade; FGFR3 R-HSA-5654228: Phospholipase C-mediated cascade; FGFR4 R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5654688: SHC-mediated cascade R-HSA-5654699: SHC-mediated cascade R-HSA-5654704: SHC-mediated cascade R-HSA-5654719: SHC-mediated cascade R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-1226099: Signaling by FGFR in disease R-HSA-5654736: Signaling by FGFR1 R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-5654738: Signaling by FGFR2 R-HSA-8851708: Signaling by FGFR2 IIIa TM R-HSA-5655253: Signaling by FGFR2 in disease R-HSA-5654741: Signaling by FGFR3 R-HSA-5655332: Signaling by FGFR3 in disease R-HSA-8853338: Signaling by FGFR3 point mutants in cancer R-HSA-5654743: Signaling by FGFR4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-1839122: Signaling by activated point mutants of FGFR1 R-HSA-1839130: Signaling by activated point mutants of FGFR3 R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04390 Hippo signaling pathway
hsa04810 Regulation of actin cytoskeleton

Reactome

R-HSA-170984: ARMS-mediated activation
R-HSA-2033519: Activated point mutants of FGFR2
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-5654708: Downstream signaling of activated FGFR3
R-HSA-5654716: Downstream signaling of activated FGFR4
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-190242: FGFR1 ligand binding and activation
R-HSA-1839124: FGFR1 mutant receptor activation
R-HSA-190370: FGFR1b ligand binding and activation
R-HSA-190373: FGFR1c ligand binding and activation
R-HSA-190241: FGFR2 ligand binding and activation
R-HSA-1839126: FGFR2 mutant receptor activation
R-HSA-190377: FGFR2b ligand binding and activation
R-HSA-190375: FGFR2c ligand binding and activation
R-HSA-190239: FGFR3 ligand binding and activation
R-HSA-2033514: FGFR3 mutant receptor activation
R-HSA-190371: FGFR3b ligand binding and activation
R-HSA-190372: FGFR3c ligand binding and activation
R-HSA-190322: FGFR4 ligand binding and activation
R-HSA-5654693: FRS-mediated FGFR1 signaling
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-5654706: FRS-mediated FGFR3 signaling
R-HSA-5654712: FRS-mediated FGFR4 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654726: Negative regulation of FGFR1 signaling
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-5654732: Negative regulation of FGFR3 signaling
R-HSA-5654733: Negative regulation of FGFR4 signaling
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-5654689: PI-3K cascade
R-HSA-5654695: PI-3K cascade
R-HSA-5654710: PI-3K cascade
R-HSA-5654720: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-5654219: Phospholipase C-mediated cascade
R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2
R-HSA-5654227: Phospholipase C-mediated cascade; FGFR3
R-HSA-5654228: Phospholipase C-mediated cascade; FGFR4
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-5654688: SHC-mediated cascade
R-HSA-5654699: SHC-mediated cascade
R-HSA-5654704: SHC-mediated cascade
R-HSA-5654719: SHC-mediated cascade
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654736: Signaling by FGFR1
R-HSA-5655302: Signaling by FGFR1 in disease
R-HSA-5654738: Signaling by FGFR2
R-HSA-8851708: Signaling by FGFR2 IIIa TM
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-5654741: Signaling by FGFR3
R-HSA-5655332: Signaling by FGFR3 in disease
R-HSA-8853338: Signaling by FGFR3 point mutants in cancer
R-HSA-5654743: Signaling by FGFR4
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-1839122: Signaling by activated point mutants of FGFR1
R-HSA-1839130: Signaling by activated point mutants of FGFR3
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FGF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between FGF1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29666124	melanoma	Inhibit immunity	Fgf1 Nuclear transcriptional profiling of neutrophils, performed as they respond to the earliest precursors of melanoma in vivo, revealed an intricate landscape of regulatory factors that may promote progression to melanoma, including Serpinb1l4, Fgf1, Fgf6, Cathepsin H, Galectin 1 and Galectin 3.

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of FGF1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FGF1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.065	0.0763
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.195	0.354
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.949	0.261
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.192	0.666
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.193	0.839
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.189	0.861
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.308	0.591
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.886	0.391
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.233	0.823
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.845	0.375
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.237	0.0536
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.519	0.0134

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of FGF1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	1.4	6	0.177
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	1.7	5.7	0.231
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FGF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FGF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FGF1
Name	fibroblast growth factor 1 (acidic)
Aliases	AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location	5q31.3-q33.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FGF1 collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting FGF1.

ID	Name	Drug Type	Targets	#Targets
DB00686	Pentosan Polysulfate	Small Molecule	FGF1, FGF2, FGF4	3
DB01025	Amlexanox	Small Molecule	FGF1, IL3, S100A12, S100A13	4
DB01109	Heparin	Small Molecule	F10, FGF1, FGF19, FGF2, FGF4, FGFR1, FGFR2, FGFR4, HGF, PF4, SELP, ......	12
DB01901	Sucrosofate	Small Molecule	FGF1, FGFR2	2
DB01942	Formic Acid	Small Molecule	ACYP2, CA2, CASK, CTBP1, CYTH2, FGF1, GGACT, GPHN, HMOX1, NOS1, PV ......	12
DB02264	O2-Sulfo-Glucuronic Acid	Small Molecule	FGF1, HGF, HS3ST3A1	3
DB03959	N,O6-Disulfo-Glucosamine	Small Molecule	ANXA5, FGF1, FGF2, HGF, HS3ST3A1	5
DB04409	Naphthalene Trisulfonate	Small Molecule	FGF1	1
DB06589	Pazopanib	Small Molecule	FGF1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B3	10
DB08238	5-AMINO-NAPHTALENE-2-MONOSULFONATE	Small Molecule	FGF1	1

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