Browse FKBP1B

Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Sarcoplasmic reticulum
Domain PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase
Function

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0000413 protein peptidyl-prolyl isomerization
GO:0001508 action potential
GO:0001678 cellular glucose homeostasis
GO:0002027 regulation of heart rate
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0006470 protein dephosphorylation
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006939 smooth muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0006979 response to oxidative stress
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010459 negative regulation of heart rate
GO:0010469 regulation of receptor activity
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010644 cell communication by electrical coupling
GO:0010720 positive regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0010921 regulation of phosphatase activity
GO:0010923 negative regulation of phosphatase activity
GO:0010959 regulation of metal ion transport
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0015833 peptide transport
GO:0016311 dephosphorylation
GO:0018208 peptidyl-proline modification
GO:0019226 transmission of nerve impulse
GO:0019227 neuronal action potential propagation
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0022417 protein maturation by protein folding
GO:0022898 regulation of transmembrane transporter activity
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0031099 regeneration
GO:0031102 neuron projection regeneration
GO:0031103 axon regeneration
GO:0031346 positive regulation of cell projection organization
GO:0031667 response to nutrient levels
GO:0032103 positive regulation of response to external stimulus
GO:0032409 regulation of transporter activity
GO:0032410 negative regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0032512 regulation of protein phosphatase type 2B activity
GO:0032513 negative regulation of protein phosphatase type 2B activity
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032943 mononuclear cell proliferation
GO:0033197 response to vitamin E
GO:0033273 response to vitamin
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0035303 regulation of dephosphorylation
GO:0035304 regulation of protein dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035308 negative regulation of protein dephosphorylation
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035637 multicellular organismal signaling
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0042026 protein refolding
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042391 regulation of membrane potential
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043271 negative regulation of ion transport
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044057 regulation of system process
GO:0045666 positive regulation of neuron differentiation
GO:0045822 negative regulation of heart contraction
GO:0046651 lymphocyte proliferation
GO:0046676 negative regulation of insulin secretion
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048678 response to axon injury
GO:0048679 regulation of axon regeneration
GO:0048680 positive regulation of axon regeneration
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050769 positive regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050848 regulation of calcium-mediated signaling
GO:0050849 negative regulation of calcium-mediated signaling
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051224 negative regulation of protein transport
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051284 positive regulation of sequestering of calcium ion
GO:0051346 negative regulation of hydrolase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051604 protein maturation
GO:0051775 response to redox state
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0051962 positive regulation of nervous system development
GO:0055074 calcium ion homeostasis
GO:0055117 regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0061077 chaperone-mediated protein folding
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061337 cardiac conduction
GO:0061564 axon development
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070509 calcium ion import
GO:0070570 regulation of neuron projection regeneration
GO:0070572 positive regulation of neuron projection regeneration
GO:0070588 calcium ion transmembrane transport
GO:0070661 leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071593 lymphocyte aggregation
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086065 cell communication involved in cardiac conduction
GO:0090087 regulation of peptide transport
GO:0090257 regulation of muscle system process
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0090279 regulation of calcium ion import
GO:0090281 negative regulation of calcium ion import
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098870 action potential propagation
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:1902532 negative regulation of intracellular signal transduction
GO:1902656 calcium ion import into cytosol
GO:1903034 regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903170 negative regulation of calcium ion transmembrane transport
GO:1903514 calcium ion transport from endoplasmic reticulum to cytosol
GO:1903522 regulation of blood circulation
GO:1903523 negative regulation of blood circulation
GO:1903531 negative regulation of secretion by cell
GO:1903779 regulation of cardiac conduction
GO:1904062 regulation of cation transmembrane transport
GO:1904063 negative regulation of cation transmembrane transport
GO:1904950 negative regulation of establishment of protein localization
GO:2000021 regulation of ion homeostasis
GO:2000272 negative regulation of receptor activity
GO:2001257 regulation of cation channel activity
GO:2001258 negative regulation of cation channel activity
Molecular Function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005216 ion channel activity
GO:0005217 intracellular ligand-gated ion channel activity
GO:0005219 ryanodine-sensitive calcium-release channel activity
GO:0005246 calcium channel regulator activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005527 macrolide binding
GO:0005528 FK506 binding
GO:0008144 drug binding
GO:0008200 ion channel inhibitor activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015276 ligand-gated ion channel activity
GO:0015278 calcium-release channel activity
GO:0016247 channel regulator activity
GO:0016248 channel inhibitor activity
GO:0016853 isomerase activity
GO:0016859 cis-trans isomerase activity
GO:0019855 calcium channel inhibitor activity
GO:0022803 passive transmembrane transporter activity
GO:0022834 ligand-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0030551 cyclic nucleotide binding
GO:0044325 ion channel binding
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
GO:0099604 ligand-gated calcium channel activity
Cellular Component GO:0016528 sarcoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031674 I band
GO:0033017 sarcoplasmic reticulum membrane
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-983712: Ion channel transport
R-HSA-5578775: Ion homeostasis
R-HSA-397014: Muscle contraction
R-HSA-2672351: Stimuli-sensing channels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FKBP1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FKBP1B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FKBP1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5920.164
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6290.584
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5730.563
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4990.487
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6670.553
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2980.81
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.410.36
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1650.842
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7470.426
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.740.432
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.2480.328
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6280.000963
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FKBP1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FKBP1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FKBP1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FKBP1B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FKBP1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FKBP1B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FKBP1B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFKBP1B
NameFK506 binding protein 1B, 12.6 kDa
Aliases OTK4; FKBP12.6; calstabin 2; FKBP1L; FK506-binding protein 1B (12.6 kD); PKBP1L; 12.6 kDa FK506-binding prot ......
Chromosomal Location2p23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FKBP1B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.