TISIDB

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.
Domain	PF01534 Frizzled/Smoothened family membrane region PF01392 Fz domain
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

> Gene Ontology [ TOP ]
Biological Process	GO:0001101 response to acid chemical GO:0001704 formation of primary germ layer GO:0001705 ectoderm formation GO:0001708 cell fate specification GO:0001712 ectodermal cell fate commitment GO:0001715 ectodermal cell fate specification GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0002521 leukocyte differentiation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007164 establishment of tissue polarity GO:0007254 JNK cascade GO:0007369 gastrulation GO:0007398 ectoderm development GO:0009996 negative regulation of cell fate specification GO:0010453 regulation of cell fate commitment GO:0010454 negative regulation of cell fate commitment GO:0010470 regulation of gastrulation GO:0010668 ectodermal cell differentiation GO:0010810 regulation of cell-substrate adhesion GO:0010812 negative regulation of cell-substrate adhesion GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0016055 Wnt signaling pathway GO:0017038 protein import GO:0017145 stem cell division GO:0019827 stem cell population maintenance GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0031098 stress-activated protein kinase signaling cascade GO:0031099 regeneration GO:0031589 cell-substrate adhesion GO:0032386 regulation of intracellular transport GO:0032526 response to retinoic acid GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033077 T cell differentiation in thymus GO:0033157 regulation of intracellular protein transport GO:0034446 substrate adhesion-dependent cell spreading GO:0034504 protein localization to nucleus GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0035567 non-canonical Wnt signaling pathway GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade GO:0038031 non-canonical Wnt signaling pathway via JNK cascade GO:0042110 T cell activation GO:0042246 tissue regeneration GO:0042306 regulation of protein import into nucleus GO:0042659 regulation of cell fate specification GO:0042665 regulation of ectodermal cell fate specification GO:0042666 negative regulation of ectodermal cell fate specification GO:0043403 skeletal muscle tissue regeneration GO:0043410 positive regulation of MAPK cascade GO:0044744 protein targeting to nucleus GO:0045165 cell fate commitment GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046822 regulation of nucleocytoplasmic transport GO:0048103 somatic stem cell division GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051403 stress-activated MAPK cascade GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060231 mesenchymal to epithelial transition GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0090175 regulation of establishment of planar polarity GO:0098727 maintenance of cell number GO:0198738 cell-cell signaling by wnt GO:1900180 regulation of protein localization to nucleus GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1904589 regulation of protein import GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000383 regulation of ectoderm development GO:2000384 negative regulation of ectoderm development GO:2000542 negative regulation of gastrulation
Molecular Function	GO:0001664 G-protein coupled receptor binding GO:0005109 frizzled binding GO:0017147 Wnt-protein binding GO:0030165 PDZ domain binding GO:0042813 Wnt-activated receptor activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04150 mTOR signaling pathway hsa04310 Wnt signaling pathway hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04916 Melanogenesis
Reactome	R-HSA-4608870: Asymmetric localization of PCP proteins R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-500792: GPCR ligand binding R-HSA-4086400: PCP/CE pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-195721: Signaling by Wnt

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FZD7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between FZD7 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29411237	Triple-Negative Breast Carcinoma	Essential for immunity	The scFvs inhibited cell growth of MDA-MB-231 cells significantly as compared to untreated cells. Growth inhibition of 58.6 and 53.1% were detected for scFv-I and scFv-II, respectively. No significant growth inhibition was detected for SKBR-3 negative control cells. The scFvs induced apoptotic effects in the MDA-MB-231 treated cells after 48?h, which were 81.6 and 74.9% for scFv-I and scFv-II, respectively. Downregulation of Surivin, c-Myc and Dvl genes were also shown after 48h treatment of cells with either of scFvs (59.3-93.8%).

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of FZD7 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FZD7 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.405	0.449
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.854	0.652
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.066	0.959
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.334	0.523
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.572	0.757
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.035	0.988
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.341	0.5
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.082	0.954
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.66	0.666
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.443	0.621
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.297	0.816
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.294	0.00957

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of FZD7 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FZD7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FZD7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FZD7. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FZD7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FZD7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FZD7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FZD7
Name	frizzled class receptor 7
Aliases	FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location	2q33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FZD7 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse FZD7