TISIDB

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm.
Domain	PF00255 Glutathione peroxidase
Function	Protects the hemoglobin in erythrocytes from oxidative breakdown.

> Gene Ontology [ TOP ]
Biological Process	GO:0000302 response to reactive oxygen species GO:0001525 angiogenesis GO:0001659 temperature homeostasis GO:0001667 ameboidal-type cell migration GO:0001836 release of cytochrome c from mitochondria GO:0001885 endothelial cell development GO:0002064 epithelial cell development GO:0002437 inflammatory response to antigenic stimulus GO:0002683 negative regulation of immune system process GO:0002861 regulation of inflammatory response to antigenic stimulus GO:0002862 negative regulation of inflammatory response to antigenic stimulus GO:0003013 circulatory system process GO:0003015 heart process GO:0003018 vascular process in circulatory system GO:0003158 endothelium development GO:0006195 purine nucleotide catabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006631 fatty acid metabolic process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006690 icosanoid metabolic process GO:0006749 glutathione metabolic process GO:0006790 sulfur compound metabolic process GO:0006979 response to oxidative stress GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007605 sensory perception of sound GO:0008015 blood circulation GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008637 apoptotic mitochondrial changes GO:0009166 nucleotide catabolic process GO:0009314 response to radiation GO:0009410 response to xenobiotic stimulus GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009608 response to symbiont GO:0009609 response to symbiotic bacterium GO:0009636 response to toxic substance GO:0009650 UV protection GO:0009894 regulation of catabolic process GO:0010035 response to inorganic substance GO:0010212 response to ionizing radiation GO:0010269 response to selenium ion GO:0010332 response to gamma radiation GO:0010466 negative regulation of peptidase activity GO:0010498 proteasomal protein catabolic process GO:0010631 epithelial cell migration GO:0010639 negative regulation of organelle organization GO:0010821 regulation of mitochondrion organization GO:0010823 negative regulation of mitochondrion organization GO:0010951 negative regulation of endopeptidase activity GO:0014706 striated muscle tissue development GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0018158 protein oxidation GO:0019372 lipoxygenase pathway GO:0019439 aromatic compound catabolic process GO:0030198 extracellular matrix organization GO:0030879 mammary gland development GO:0031099 regeneration GO:0031329 regulation of cellular catabolic process GO:0031348 negative regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0033194 response to hydroperoxide GO:0033598 mammary gland epithelial cell proliferation GO:0033599 regulation of mammary gland epithelial cell proliferation GO:0034599 cellular response to oxidative stress GO:0034655 nucleobase-containing compound catabolic process GO:0035150 regulation of tube size GO:0036473 cell death in response to oxidative stress GO:0040029 regulation of gene expression, epigenetic GO:0042176 regulation of protein catabolic process GO:0042246 tissue regeneration GO:0042311 vasodilation GO:0042542 response to hydrogen peroxide GO:0042692 muscle cell differentiation GO:0042743 hydrogen peroxide metabolic process GO:0042744 hydrogen peroxide catabolic process GO:0043062 extracellular structure organization GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043403 skeletal muscle tissue regeneration GO:0043491 protein kinase B signaling GO:0043523 regulation of neuron apoptotic process GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044270 cellular nitrogen compound catabolic process GO:0045444 fat cell differentiation GO:0045446 endothelial cell differentiation GO:0045454 cell redox homeostasis GO:0045861 negative regulation of proteolysis GO:0046434 organophosphate catabolic process GO:0046486 glycerolipid metabolic process GO:0046700 heterocycle catabolic process GO:0048514 blood vessel morphogenesis GO:0048732 gland development GO:0048741 skeletal muscle fiber development GO:0048747 muscle fiber development GO:0048871 multicellular organismal homeostasis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050777 negative regulation of immune response GO:0050880 regulation of blood vessel size GO:0050954 sensory perception of mechanical stimulus GO:0051146 striated muscle cell differentiation GO:0051346 negative regulation of hydrolase activity GO:0051402 neuron apoptotic process GO:0051450 myoblast proliferation GO:0051702 interaction with symbiont GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060047 heart contraction GO:0060055 angiogenesis involved in wound healing GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0061136 regulation of proteasomal protein catabolic process GO:0061180 mammary gland epithelium development GO:0070997 neuron death GO:0072523 purine-containing compound catabolic process GO:0072593 reactive oxygen species metabolic process GO:0090066 regulation of anatomical structure size GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090199 regulation of release of cytochrome c from mitochondria GO:0090201 negative regulation of release of cytochrome c from mitochondria GO:0097191 extrinsic apoptotic signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:0097435 fibril organization GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1901214 regulation of neuron death GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1902903 regulation of fibril organization GO:1902905 positive regulation of fibril organization GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903053 regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:1903362 regulation of cellular protein catabolic process GO:1990748 cellular detoxification GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function	GO:0004601 peroxidase activity GO:0004602 glutathione peroxidase activity GO:0016209 antioxidant activity GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO:0017124 SH3 domain binding
Cellular Component	GO:0005759 mitochondrial matrix GO:0016234 inclusion body GO:0097413 Lewy body

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04918 Thyroid hormone synthesis hsa00480 Glutathione metabolism hsa00590 Arachidonic acid metabolism
Reactome	R-HSA-2142753: Arachidonic acid metabolism R-HSA-2262752: Cellular responses to stress R-HSA-3299685: Detoxification of Reactive Oxygen Species R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-15869: Metabolism of nucleotides R-HSA-74259: Purine catabolism R-HSA-73847: Purine metabolism R-HSA-2142712: Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142688: Synthesis of 5-eicosatetraenoic acids

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04918 Thyroid hormone synthesis
hsa00480 Glutathione metabolism
hsa00590 Arachidonic acid metabolism

Reactome

R-HSA-2142753: Arachidonic acid metabolism
R-HSA-2262752: Cellular responses to stress
R-HSA-3299685: Detoxification of Reactive Oxygen Species
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-15869: Metabolism of nucleotides
R-HSA-74259: Purine catabolism
R-HSA-73847: Purine metabolism
R-HSA-2142712: Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-2142688: Synthesis of 5-eicosatetraenoic acids

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between GPX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of GPX1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: -1.74; FDR: 0.04220	Resistant to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of GPX1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.05	0.882
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.102	0.981
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.007	0.998
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.414	0.394
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.367	0.88
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.474	0.879
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.334	0.505
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.491	0.801
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.288	0.902
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.097	0.97
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.371	0.928
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.136	0.139

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of GPX1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	2.7	4.7	0.294
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	14.3	-14.3	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	0	7.4	0.096
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPX1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of GPX1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between GPX1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	GPX1
Name	glutathione peroxidase 1
Aliases	GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location	3p21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting GPX1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting GPX1.

ID	Name	Drug Type	Targets	#Targets
DB00143	Glutathione	Small Molecule	AKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......	41

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