Browse HEYL

Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF07527 Hairy Orange
PF00010 Helix-loop-helix DNA-binding domain
Function

Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003170 heart valve development
GO:0003171 atrioventricular valve development
GO:0003177 pulmonary valve development
GO:0003179 heart valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003231 cardiac ventricle development
GO:0003272 endocardial cushion formation
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0009755 hormone-mediated signaling pathway
GO:0010469 regulation of receptor activity
GO:0010720 positive regulation of cell development
GO:0014031 mesenchymal cell development
GO:0014706 striated muscle tissue development
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0032835 glomerulus development
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0035914 skeletal muscle cell differentiation
GO:0043401 steroid hormone mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045666 positive regulation of neuron differentiation
GO:0048545 response to steroid hormone
GO:0048762 mesenchymal cell differentiation
GO:0050769 positive regulation of neurogenesis
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051962 positive regulation of nervous system development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061326 renal tubule development
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072014 proximal tubule development
GO:0072073 kidney epithelium development
GO:0072080 nephron tubule development
GO:0072132 mesenchyme morphogenesis
GO:1905314 semi-lunar valve development
GO:2000272 negative regulation of receptor activity
GO:2000823 regulation of androgen receptor activity
GO:2000824 negative regulation of androgen receptor activity
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003696 satellite DNA binding
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0035939 microsatellite binding
GO:0046982 protein heterodimerization activity
GO:0050683 AF-1 domain binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HEYL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HEYL in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HEYL in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.010.00987
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.4120.161
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7120.346
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4290.306
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4930.748
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3460.862
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4470.311
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2890.777
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6110.59
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.210.388
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.2980.231
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4740.000801
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HEYL in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HEYL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HEYL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HEYL.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HEYL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HEYL expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HEYL and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHEYL
Namehes-related family bHLH transcription factor with YRPW motif-like
Aliases bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HEYL collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.