Browse HIST1H1B

Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.
Domain PF00538 linker histone H1 and H5 family
Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006479 protein methylation
GO:0008213 protein alkylation
GO:0016049 cell growth
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0018022 peptidyl-lysine methylation
GO:0018205 peptidyl-lysine modification
GO:0030307 positive regulation of cell growth
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031060 regulation of histone methylation
GO:0031062 positive regulation of histone methylation
GO:0031497 chromatin assembly
GO:0031647 regulation of protein stability
GO:0032259 methylation
GO:0034502 protein localization to chromosome
GO:0034728 nucleosome organization
GO:0034968 histone lysine methylation
GO:0043414 macromolecule methylation
GO:0045927 positive regulation of growth
GO:0050821 protein stabilization
GO:0051567 histone H3-K9 methylation
GO:0051570 regulation of histone H3-K9 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0061647 histone H3-K9 modification
GO:0065004 protein-DNA complex assembly
GO:0070199 establishment of protein localization to chromosome
GO:0071103 DNA conformation change
GO:0071168 protein localization to chromatin
GO:0071169 establishment of protein localization to chromatin
GO:0071824 protein-DNA complex subunit organization
GO:1902275 regulation of chromatin organization
GO:1905269 positive regulation of chromatin organization
Molecular Function GO:0003682 chromatin binding
GO:0031490 chromatin DNA binding
GO:0042826 histone deacetylase binding
GO:0043566 structure-specific DNA binding
Cellular Component GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005720 nuclear heterochromatin
GO:0032993 protein-DNA complex
GO:0044454 nuclear chromosome part
GO:0044815 DNA packaging complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-211227: Activation of DNA fragmentation factor
R-HSA-109581: Apoptosis
R-HSA-140342: Apoptosis induced DNA fragmentation
R-HSA-75153: Apoptotic execution phase
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence
R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-5357801: Programmed Cell Death
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HIST1H1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HIST1H1B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HIST1H1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0130.963
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2040.693
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1710.693
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2650.695
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5710.777
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.120.962
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.4130.0311
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5670.0693
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3740.0491
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HIST1H1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIST1H1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIST1H1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIST1H1B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIST1H1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HIST1H1B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HIST1H1B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHIST1H1B
Namehistone cluster 1, H1b
Aliases H1.5; H1b; H1s-3; H1F5; H1 histone family, member 5; histone 1, H1b; histone H1s-3; Histone H1.5
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HIST1H1B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.