Browse HOXA7

Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00046 Homeobox domain
Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001952 regulation of cell-matrix adhesion
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002685 regulation of leukocyte migration
GO:0002686 negative regulation of leukocyte migration
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0003002 regionalization
GO:0007160 cell-matrix adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007389 pattern specification process
GO:0008544 epidermis development
GO:0009913 epidermal cell differentiation
GO:0009952 anterior/posterior pattern specification
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0030099 myeloid cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030224 monocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030856 regulation of epithelial cell differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031589 cell-substrate adhesion
GO:0040013 negative regulation of locomotion
GO:0043588 skin development
GO:0045604 regulation of epidermal cell differentiation
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045655 regulation of monocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045682 regulation of epidermis development
GO:0045683 negative regulation of epidermis development
GO:0048514 blood vessel morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048863 stem cell differentiation
GO:0050900 leukocyte migration
GO:0051271 negative regulation of cellular component movement
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1903131 mononuclear cell differentiation
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:2000146 negative regulation of cell motility
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008134 transcription factor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HOXA7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HOXA7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HOXA7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.810.161
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.5270.158
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2850.751
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.940.0295
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8730.402
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0320.454
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1460.841
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4990.634
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1620.909
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3120.795
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2090.894
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.160.45
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HOXA7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HOXA7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HOXA7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHOXA7
Namehomeobox A7
Aliases HOX1A; homeo box A7; ANTP; HOX1.1; homeobox protein HOX-1A; homeobox protein Hox 1.1; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HOXA7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.