TISIDB

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Domain	PF00001 7 transmembrane receptor (rhodopsin family)
Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

> Gene Ontology [ TOP ]
Biological Process	GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0007210 serotonin receptor signaling pathway GO:0007623 circadian rhythm GO:0008015 blood circulation GO:0035150 regulation of tube size GO:0042310 vasoconstriction GO:0048511 rhythmic process GO:0050880 regulation of blood vessel size GO:0090066 regulation of anatomical structure size
Molecular Function	GO:0004993 G-protein coupled serotonin receptor activity GO:0008227 G-protein coupled amine receptor activity GO:0030594 neurotransmitter receptor activity GO:0099589 serotonin receptor activity
Cellular Component	GO:0030425 dendrite

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04014 Ras signaling pathway hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04726 Serotonergic synapse
Reactome	R-HSA-375280: Amine ligand-binding receptors R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-390666: Serotonin receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between HTR7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of HTR7 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of HTR7 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.588	0.119
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.865	0.167
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.379	0.486
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.27	0.586
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.205	0.851
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.345	0.77
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.543	0.329
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.223	0.149
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.322	0.711
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.185	0.688
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.58	0.354
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.919	0.00107

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of HTR7 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HTR7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HTR7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HTR7. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HTR7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of HTR7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between HTR7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	HTR7
Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Aliases	5-HT7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT-7; 5-HT-X; Serotonin rec ......
Chromosomal Location	10q21-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting HTR7 collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting HTR7.

ID	Name	Drug Type	Targets	#Targets
DB00216	Eletriptan	Small Molecule	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2B, HTR7	7
DB00246	Ziprasidone	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......	25
DB00247	Methysergide	Small Molecule	HTR1A, HTR1B, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR7	8
DB00248	Cabergoline	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1 ......	22
DB00321	Amitriptyline	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......	35
DB00334	Olanzapine	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......	50
DB00363	Clozapine	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, ......	27
DB00370	Mirtazapine	Small Molecule	ADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......	23
DB00408	Loxapine	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......	34
DB00434	Cyproheptadine	Small Molecule	CHRM1, CHRM2, CHRM3, HRH1, HTR2A, HTR2C, HTR7	7
DB00458	Imipramine	Small Molecule	ADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......	25
DB00477	Chlorpromazine	Small Molecule	ADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......	31
DB00543	Amoxapine	Small Molecule	ADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......	48
DB00589	Lisuride	Small Molecule	ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......	15
DB00734	Risperidone	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HR ......	15
DB00751	Epinastine	Small Molecule	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	6
DB00934	Maprotiline	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......	17
DB00988	Dopamine	Small Molecule	DBH, DRD1, DRD1, DRD2, DRD3, DRD4, DRD5, DRD5, HTR1A, HTR3A, HTR3B ......	17
DB01049	Ergoloid mesylate	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, GABRA1 ......	41
DB01200	Bromocriptine	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......	18
DB01224	Quetiapine	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......	26
DB01238	Aripiprazole	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......	25
DB01267	Paliperidone	Small Molecule	ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CYP2D6, CYP3A4, CYP3A5, DR ......	18
DB04946	Iloperidone	Small Molecule	ADRA1A, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR2A, HTR6, ......	11
DB06148	Mianserin	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......	23
DB06216	Asenapine	Small Molecule	ADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DR ......	20
DB06288	Amisulpride	Small Molecule	DRD2, DRD3, HTR2A, HTR7	4
DB08815	Lurasidone	Small Molecule	ADRA2A, ADRA2C, DRD2, HTR1A, HTR2A, HTR7	6
DB09068	Vortioxetine	Small Molecule	ADRB1, HTR1A, HTR1B, HTR3A, HTR7, SLC6A4	6
DB09225	Zotepine	Small Molecule	DRD1, DRD2, DRD5, HTR2A, HTR6, HTR7, SLC6A2, SLC6A4	8
DB09304	Setiptiline	Small Molecule	ADRA2A, ADRA2B, ADRA2C, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, ......	19
DB13025	Tiapride	Small Molecule	ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HRH1, ......	25
DB13988	SB-269970	Small Molecule	HTR7	1

Browse HTR7