Browse ITGA5

Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion Cell surface
Domain PF01839 FG-GAP repeat
PF08441 Integrin alpha
Function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. ; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. ; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001704 formation of primary germ layer
GO:0001706 endoderm formation
GO:0002011 morphogenesis of an epithelial sheet
GO:0002040 sprouting angiogenesis
GO:0007044 cell-substrate junction assembly
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0007611 learning or memory
GO:0007613 memory
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019058 viral life cycle
GO:0030198 extracellular matrix organization
GO:0030260 entry into host cell
GO:0030335 positive regulation of cell migration
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0033627 cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0035313 wound healing, spreading of epidermal cells
GO:0035987 endodermal cell differentiation
GO:0040017 positive regulation of locomotion
GO:0043062 extracellular structure organization
GO:0043276 anoikis
GO:0044319 wound healing, spreading of cells
GO:0044409 entry into host
GO:0044708 single-organism behavior
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0046718 viral entry into host cell
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050890 cognition
GO:0050900 leukocyte migration
GO:0051272 positive regulation of cellular component movement
GO:0051701 interaction with host
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090504 epiboly
GO:0090505 epiboly involved in wound healing
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:1901342 regulation of vasculature development
GO:1903670 regulation of sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904018 positive regulation of vasculature development
GO:2000147 positive regulation of cell motility
GO:2000209 regulation of anoikis
GO:2000811 negative regulation of anoikis
Molecular Function GO:0001618 virus receptor activity
GO:0005126 cytokine receptor binding
GO:0005154 epidermal growth factor receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005178 integrin binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0050839 cell adhesion molecule binding
GO:0070851 growth factor receptor binding
Cellular Component GO:0001726 ruffle
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0030055 cell-substrate junction
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032587 ruffle membrane
GO:0043235 receptor complex
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:0098552 side of membrane
GO:0098636 protein complex involved in cell adhesion
GO:0098802 plasma membrane receptor complex
> KEGG and Reactome Pathway
 
KEGG hsa04145 Phagosome
hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
hsa04640 Hematopoietic cell lineage
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-422475: Axon guidance
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-1266738: Developmental Biology
R-HSA-1566948: Elastic fibre formation
R-HSA-1474244: Extracellular matrix organization
R-HSA-1566977: Fibronectin matrix formation
R-HSA-109582: Hemostasis
R-HSA-216083: Integrin cell surface interactions
R-HSA-373760: L1CAM interactions
R-HSA-445144: Signal transduction by L1
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ITGA5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ITGA5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ITGA5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.4360.00345
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.5830.497
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.3090.36
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9750.148
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6740.817
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.3540.712
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2620.686
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0170.992
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5740.775
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.4540.461
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.5310.375
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4440.00885
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ITGA5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.54.114.40.0315
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.55.113.40.102
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.37.4-2.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 2213015.4-15.40.131
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ITGA5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ITGA5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolITGA5
Nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Aliases CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ......
Chromosomal Location12q11-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ITGA5 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ITGA5.
ID Name Drug Type Targets #Targets
DB02709ResveratrolSmall MoleculeAHR, AKT1, ALOX15, ALOX5, APP, CBR1, CLEC14A, CSNK2A1, ESR1, ITGA5 ......25