Browse ITGAX

Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein.
Domain PF01839 FG-GAP repeat
PF00357 Integrin alpha cytoplasmic region
PF08441 Integrin alpha
PF00092 von Willebrand factor type A domain
Function

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

> Gene Ontology
 
Biological Process GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0007229 integrin-mediated signaling pathway
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0030198 extracellular matrix organization
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0034113 heterotypic cell-cell adhesion
GO:0043062 extracellular structure organization
GO:0050900 leukocyte migration
GO:0051222 positive regulation of protein transport
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0090316 positive regulation of intracellular protein transport
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903533 regulation of protein targeting
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904951 positive regulation of establishment of protein localization
Molecular Function -
Cellular Component GO:0008305 integrin complex
GO:0043235 receptor complex
GO:0098636 protein complex involved in cell adhesion
GO:0098802 plasma membrane receptor complex
> KEGG and Reactome Pathway
 
KEGG hsa04610 Complement and coagulation cascades
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-3000178: ECM proteoglycans
R-HSA-1474244: Extracellular matrix organization
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-216083: Integrin cell surface interactions
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-6798695: Neutrophil degranulation
R-HSA-449147: Signaling by Interleukins
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ITGAX and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ITGAX and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29674449lung carcinomaPromote immunity (T&NK cell function); increase the efficacy of immunotherapyThe ihv-DCs are a subset of CD11c+/CD205+ DCs that constitutively display costimulatory molecules.
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ITGAX in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ITGAX in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1920.603
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.360.78
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0740.934
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3030.638
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0930.629
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7090.827
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1120.834
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2530.861
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0490.975
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.5340.265
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9060.334
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2570.192
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ITGAX in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.18.22.90.699
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.110.20.91
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117029.4-29.40.0123
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311045.5-45.50.0109
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.115.4-6.30.618
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGAX. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGAX. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGAX.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGAX. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ITGAX expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ITGAX and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolITGAX
Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Aliases CD11c; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); CD11 antigen-like family member C; leu M ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ITGAX collected from DrugBank database.
> Drugs from DrugBank database
 

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