Browse MARCKSL1

Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell membrane Membrane Lipid-anchor Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity).
Domain PF02063 MARCKS family
Function

Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

> Gene Ontology
 
Biological Process -
Molecular Function GO:0003779 actin binding
GO:0005516 calmodulin binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04666 Fc gamma R-mediated phagocytosis
Reactome -
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MARCKSL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MARCKSL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 0.20; FDR: 0.006430 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MARCKSL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3810.382
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3670.917
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3960.881
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4010.488
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5310.799
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2420.93
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1270.804
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0560.979
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4220.851
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.430.817
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.80.772
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2440.0325
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MARCKSL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MARCKSL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MARCKSL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MARCKSL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MARCKSL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MARCKSL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMARCKSL1
NameMARCKS-like 1
Aliases F52; MacMARCKS; MARCKS-like protein; MARCKS-like protein 1; mac-MARCKS; macrophage myristoylated alanine-ric ......
Chromosomal Location1p35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MARCKSL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.