TISIDB

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm
Domain	PF07728 AAA domain (dynein-related subfamily)
Function	Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0000027 ribosomal large subunit assembly GO:0006364 rRNA processing GO:0016072 rRNA metabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0034470 ncRNA processing GO:0042254 ribosome biogenesis GO:0042255 ribosome assembly GO:0042273 ribosomal large subunit biogenesis GO:0071826 ribonucleoprotein complex subunit organization
Molecular Function	GO:0016887 ATPase activity GO:0051082 unfolded protein binding
Cellular Component	GO:0030684 preribosome GO:0030687 preribosome, large subunit precursor GO:0045111 intermediate filament cytoskeleton

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03008 Ribosome biogenesis in eukaryotes
Reactome	-

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MDN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of MDN1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of MDN1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.112	0.597
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.562	0.573
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.215	0.768
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.12	0.643
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.063	0.982
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.192	0.957
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.452	0.222
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.437	0.784
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.481	0.786
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.357	0.693
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.079	0.954
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.041	0.436

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MDN1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	8.2	6.6	0.452
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	10.2	4.6	0.718
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	28.6	0	28.6	0.0241
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	25	0	25	0.473
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	30.8	0	30.8	0.0983
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	18.8	-7.7	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	22.2	-22.2	0.505
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	14.3	10.7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	10.5	7.4	3.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	18.2	0	18.2	0.274
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	14.3	-14.3	0.209
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MDN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MDN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MDN1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MDN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MDN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MDN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MDN1
Name	midasin AAA ATPase 1
Aliases	KIAA0301; Rea1; MDN1, midasin homolog (yeast); MDN1, midasin homolog; MIDAS-containing protein; Midasin
Chromosomal Location	6q15
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MDN1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse MDN1