TISIDB

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus. Nucleus speckle.
Domain	-
Function	Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.

> Gene Ontology [ TOP ]
Biological Process	GO:0001933 negative regulation of protein phosphorylation GO:0006479 protein methylation GO:0007254 JNK cascade GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0031098 stress-activated protein kinase signaling cascade GO:0032259 methylation GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0034968 histone lysine methylation GO:0042326 negative regulation of phosphorylation GO:0043409 negative regulation of MAPK cascade GO:0043414 macromolecule methylation GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0051403 stress-activated MAPK cascade GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0071425 hematopoietic stem cell proliferation GO:0072089 stem cell proliferation GO:1902532 negative regulation of intracellular signal transduction
Molecular Function	GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity
Cellular Component	GO:0000118 histone deacetylase complex GO:0016234 inclusion body GO:0016235 aggresome GO:0016604 nuclear body GO:0016607 nuclear speck

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214841: PKMTs methylate histone lysines

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MECOM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of MECOM in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of MECOM in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.863	0.015
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.971	0.18
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.786	0.195
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.254	0.594
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.625	0.809
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.198	0.945
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.571	0.245
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.677	0.499
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.437	0.696
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.274	0.787
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.399	0.277
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.286	0.166

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MECOM in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	25.9	12.3	13.6	0.126
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	25.9	15.3	10.6	0.248
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	23.8	23.5	0.3	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	30.8	36.4	-5.6	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	22.2	6.2	16	0.53
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	21.1	7.4	13.7	0.175
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	27.3	0	27.3	0.0645
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	12.5	14.3	-1.8	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	7.7	1.4	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	16.7	0	16.7	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MECOM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MECOM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MECOM. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MECOM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MECOM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MECOM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MECOM
Name	MDS1 and EVI1 complex locus
Aliases	MDS1-EVI1; PRDM3; MDS1; EVI1; myelodysplasia syndrome 1; ecotropic viral integration site 1; MDS1 and EVI1 c ......
Chromosomal Location	3q26.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MECOM collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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