Browse MPV17L

Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Peroxisome membrane Multi-pass membrane protein.
Domain PF04117 Mpv17 / PMP22 family
Function

Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes.

> Gene Ontology
 
Biological Process GO:0006839 mitochondrial transport
GO:0007006 mitochondrial membrane organization
GO:0008637 apoptotic mitochondrial changes
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010639 negative regulation of organelle organization
GO:0010727 negative regulation of hydrogen peroxide metabolic process
GO:0010728 regulation of hydrogen peroxide biosynthetic process
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
GO:0010821 regulation of mitochondrion organization
GO:0010823 negative regulation of mitochondrion organization
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0042743 hydrogen peroxide metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051051 negative regulation of transport
GO:0072593 reactive oxygen species metabolic process
GO:0090559 regulation of membrane permeability
GO:0097345 mitochondrial outer membrane permeabilization
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
Molecular Function -
Cellular Component GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0031903 microbody membrane
GO:0042579 microbody
GO:0044438 microbody part
GO:0044439 peroxisomal part
> KEGG and Reactome Pathway
 
KEGG hsa04146 Peroxisome
Reactome -
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MPV17L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MPV17L in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MPV17L in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0130.972
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5330.376
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3760.471
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2730.306
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3870.765
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1320.937
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0660.93
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.9290.395
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.9010.434
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.7370.0254
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-2.1240.0333
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3570.191
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MPV17L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MPV17L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MPV17L.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MPV17L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MPV17L expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MPV17L and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMPV17L
NameMPV17 mitochondrial membrane protein-like
Aliases FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ......
Chromosomal Location16p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MPV17L collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.