Browse NGFR

Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein.
Domain PF00531 Death domain
PF00020 TNFR/NGFR cysteine-rich region
Function

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002237 response to molecule of bacterial origin
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007623 circadian rhythm
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0010466 negative regulation of peptidase activity
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010827 regulation of glucose transport
GO:0010950 positive regulation of endopeptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0016525 negative regulation of angiogenesis
GO:0022604 regulation of cell morphogenesis
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031345 negative regulation of cell projection organization
GO:0031346 positive regulation of cell projection organization
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032922 circadian regulation of gene expression
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033500 carbohydrate homeostasis
GO:0033619 membrane protein proteolysis
GO:0034504 protein localization to nucleus
GO:0034612 response to tumor necrosis factor
GO:0038179 neurotrophin signaling pathway
GO:0042593 glucose homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0044381 glucose import in response to insulin stimulus
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045765 regulation of angiogenesis
GO:0045861 negative regulation of proteolysis
GO:0045862 positive regulation of proteolysis
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051346 negative regulation of hydrolase activity
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0061564 axon development
GO:0061614 pri-miRNA transcription from RNA polymerase II promoter
GO:0071356 cellular response to tumor necrosis factor
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0097485 neuron projection guidance
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903670 regulation of sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:1903829 positive regulation of cellular protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001273 regulation of glucose import in response to insulin stimulus
Molecular Function GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005035 death receptor activity
GO:0017016 Ras GTPase binding
GO:0017137 Rab GTPase binding
GO:0019838 growth factor binding
GO:0031267 small GTPase binding
GO:0031625 ubiquitin protein ligase binding
GO:0043121 neurotrophin binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0048406 nerve growth factor binding
GO:0051020 GTPase binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04151 PI3K-Akt signaling pathway
hsa04722 Neurotrophin signaling pathway
Reactome R-HSA-193634: Axonal growth inhibition (RHOA activation)
R-HSA-209563: Axonal growth stimulation
R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE
R-HSA-193681: Ceramide signalling
R-HSA-205025: NADE modulates death signalling
R-HSA-209560: NF-kB is activated and signals survival
R-HSA-205017: NFG and proNGF binds to p75NTR
R-HSA-193648: NRAGE signals death through JNK
R-HSA-205043: NRIF signals cell death from the nucleus
R-HSA-193692: Regulated proteolysis of p75NTR
R-HSA-162582: Signal Transduction
R-HSA-166520: Signalling by NGF
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-193670: p75NTR negatively regulates cell cycle via SC1
R-HSA-209543: p75NTR recruits signalling complexes
R-HSA-193697: p75NTR regulates axonogenesis
R-HSA-193639: p75NTR signals via NF-kB
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NGFR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NGFR and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29619024MelanomaPromote immunityIn conclusion, we have demonstrated that the incorporation of the NGFR marker gene within the CAR sequence allows for a single molecule to simultaneously work as a therapeutic and selection/tracking gene.
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NGFR in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NGFR in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3040.571
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0290.984
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5380.597
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4480.46
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1780.901
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.2350.498
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.460.462
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3370.789
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5370.709
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.680.553
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.7430.235
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7960.00282
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NGFR in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NGFR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NGFR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NGFR.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NGFR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NGFR expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NGFR and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNGFR
Namenerve growth factor receptor
Aliases TNFRSF16; CD271; p75NTR; low affinity nerve growth factor receptor; TNFR superfamily, member 16; nerve growt ......
Chromosomal Location17q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NGFR collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.