Browse NME5

Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF05186 Dpy-30 motif
PF00334 Nucleoside diphosphate kinase
Function

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

> Gene Ontology
 
Biological Process GO:0003341 cilium movement
GO:0003351 epithelial cilium movement
GO:0006164 purine nucleotide biosynthetic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006979 response to oxidative stress
GO:0007018 microtubule-based movement
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009145 purine nucleoside triphosphate biosynthetic process
GO:0009147 pyrimidine nucleoside triphosphate metabolic process
GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009206 purine ribonucleoside triphosphate biosynthetic process
GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process
GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process
GO:0009218 pyrimidine ribonucleotide metabolic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0010927 cellular component assembly involved in morphogenesis
GO:0021591 ventricular system development
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030031 cell projection assembly
GO:0034599 cellular response to oxidative stress
GO:0036473 cell death in response to oxidative stress
GO:0042278 purine nucleoside metabolic process
GO:0042384 cilium assembly
GO:0042451 purine nucleoside biosynthetic process
GO:0042455 ribonucleoside biosynthetic process
GO:0044782 cilium organization
GO:0046036 CTP metabolic process
GO:0046039 GTP metabolic process
GO:0046051 UTP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046129 purine ribonucleoside biosynthetic process
GO:0046131 pyrimidine ribonucleoside metabolic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046939 nucleotide phosphorylation
GO:0048232 male gamete generation
GO:0048515 spermatid differentiation
GO:0060271 cilium morphogenesis
GO:0072522 purine-containing compound biosynthetic process
GO:0072527 pyrimidine-containing compound metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901068 guanosine-containing compound metabolic process
GO:1901070 guanosine-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0004550 nucleoside diphosphate kinase activity
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019205 nucleobase-containing compound kinase activity
Cellular Component GO:0005929 cilium
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0097223 sperm part
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NME5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NME5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NME5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5670.167
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1060.906
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.9050.194
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0790.857
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3370.702
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2510.797
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1010.834
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2930.707
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0990.905
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.3760.299
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.590.359
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3490.128
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NME5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NME5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NME5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NME5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NME5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NME5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NME5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNME5
NameNME/NM23 family member 5
Aliases nm23-H5; RSPH23; radial spoke 23 homolog (Chlamydomonas); non-metastatic cells 5, protein expressed in (nucl ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NME5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.