Browse PDGFB

Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted. Note=Released by platelets upon wounding.
Domain PF00341 PDGF/VEGF domain
PF04692 Platelet-derived growth factor
Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

> Gene Ontology
 
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000271 polysaccharide biosynthetic process
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001667 ameboidal-type cell migration
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001977 renal system process involved in regulation of blood volume
GO:0002064 epithelial cell development
GO:0002548 monocyte chemotaxis
GO:0002576 platelet degranulation
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003093 regulation of glomerular filtration
GO:0003094 glomerular filtration
GO:0003104 positive regulation of glomerular filtration
GO:0005976 polysaccharide metabolic process
GO:0006022 aminoglycan metabolic process
GO:0006023 aminoglycan biosynthetic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006816 calcium ion transport
GO:0006887 exocytosis
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0008654 phospholipid biosynthetic process
GO:0010511 regulation of phosphatidylinositol biosynthetic process
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010543 regulation of platelet activation
GO:0010544 negative regulation of platelet activation
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010959 regulation of metal ion transport
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014812 muscle cell migration
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016051 carbohydrate biosynthetic process
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030213 hyaluronan biosynthetic process
GO:0030258 lipid modification
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0031952 regulation of protein autophosphorylation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032091 negative regulation of protein binding
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032835 glomerulus development
GO:0032881 regulation of polysaccharide metabolic process
GO:0032885 regulation of polysaccharide biosynthetic process
GO:0033002 muscle cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035787 cell migration involved in kidney development
GO:0035788 cell migration involved in metanephros development
GO:0035789 metanephric mesenchymal cell migration
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0035886 vascular smooth muscle cell differentiation
GO:0036166 phenotypic switching
GO:0038001 paracrine signaling
GO:0040017 positive regulation of locomotion
GO:0042692 muscle cell differentiation
GO:0043062 extracellular structure organization
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043270 positive regulation of ion transport
GO:0043393 regulation of protein binding
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043696 dedifferentiation
GO:0043697 cell dedifferentiation
GO:0044057 regulation of system process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045017 glycerolipid biosynthetic process
GO:0045055 regulated exocytosis
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740 positive regulation of DNA replication
GO:0045787 positive regulation of cell cycle
GO:0045833 negative regulation of lipid metabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0045931 positive regulation of mitotic cell cycle
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0046890 regulation of lipid biosynthetic process
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050819 negative regulation of coagulation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050918 positive chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051145 smooth muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051272 positive regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051781 positive regulation of cell division
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:0061005 cell differentiation involved in kidney development
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061437 renal system vasculature development
GO:0061440 kidney vasculature development
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061614 pri-miRNA transcription from RNA polymerase II promoter
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070509 calcium ion import
GO:0070528 protein kinase C signaling
GO:0070673 response to interleukin-18
GO:0070838 divalent metal ion transport
GO:0071071 regulation of phospholipid biosynthetic process
GO:0071072 negative regulation of phospholipid biosynthetic process
GO:0071351 cellular response to interleukin-18
GO:0071505 response to mycophenolic acid
GO:0071506 cellular response to mycophenolic acid
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071674 mononuclear cell migration
GO:0071897 DNA biosynthetic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072007 mesangial cell differentiation
GO:0072008 glomerular mesangial cell differentiation
GO:0072012 glomerulus vasculature development
GO:0072109 glomerular mesangium development
GO:0072110 glomerular mesangial cell proliferation
GO:0072111 cell proliferation involved in kidney development
GO:0072124 regulation of glomerular mesangial cell proliferation
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072143 mesangial cell development
GO:0072144 glomerular mesangial cell development
GO:0072202 cell differentiation involved in metanephros development
GO:0072209 metanephric mesangial cell differentiation
GO:0072210 metanephric nephron development
GO:0072215 regulation of metanephros development
GO:0072216 positive regulation of metanephros development
GO:0072223 metanephric glomerular mesangium development
GO:0072224 metanephric glomerulus development
GO:0072239 metanephric glomerulus vasculature development
GO:0072254 metanephric glomerular mesangial cell differentiation
GO:0072255 metanephric glomerular mesangial cell development
GO:0072511 divalent inorganic cation transport
GO:0072593 reactive oxygen species metabolic process
GO:0090068 positive regulation of cell cycle process
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0090192 regulation of glomerulus development
GO:0090193 positive regulation of glomerulus development
GO:0090218 positive regulation of lipid kinase activity
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0090677 reversible differentiation
GO:0090678 cell dedifferentiation involved in phenotypic switching
GO:0097205 renal filtration
GO:0097529 myeloid leukocyte migration
GO:0098801 regulation of renal system process
GO:1900046 regulation of hemostasis
GO:1900047 negative regulation of hemostasis
GO:1900125 regulation of hyaluronan biosynthetic process
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1900238 regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:1900239 regulation of phenotypic switching
GO:1900241 positive regulation of phenotypic switching
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901722 regulation of cell proliferation involved in kidney development
GO:1901724 positive regulation of cell proliferation involved in kidney development
GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1903510 mucopolysaccharide metabolic process
GO:1903725 regulation of phospholipid metabolic process
GO:1903726 negative regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:1904018 positive regulation of vasculature development
GO:1904029 regulation of cyclin-dependent protein kinase activity
GO:1904031 positive regulation of cyclin-dependent protein kinase activity
GO:1904238 pericyte cell differentiation
GO:1904705 regulation of vascular smooth muscle cell proliferation
GO:1904707 positive regulation of vascular smooth muscle cell proliferation
GO:1904738 vascular associated smooth muscle cell migration
GO:1904752 regulation of vascular associated smooth muscle cell migration
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1905063 regulation of vascular smooth muscle cell differentiation
GO:1905064 negative regulation of vascular smooth muscle cell differentiation
GO:1905174 regulation of vascular smooth muscle cell dedifferentiation
GO:1905176 positive regulation of vascular smooth muscle cell dedifferentiation
GO:1990874 vascular smooth muscle cell proliferation
GO:1990936 vascular smooth muscle cell dedifferentiation
GO:2000147 positive regulation of cell motility
GO:2000278 regulation of DNA biosynthetic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000589 regulation of metanephric mesenchymal cell migration
GO:2000591 positive regulation of metanephric mesenchymal cell migration
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005518 collagen binding
GO:0008047 enzyme activator activity
GO:0008083 growth factor activity
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0019838 growth factor binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0042056 chemoattractant activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048407 platelet-derived growth factor binding
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:0070851 growth factor receptor binding
Cellular Component GO:0005788 endoplasmic reticulum lumen
GO:0016323 basolateral plasma membrane
GO:0030141 secretory granule
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04540 Gap junction
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1474244: Extracellular matrix organization
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PDGFB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PDGFB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PDGFB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8480.0205
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8130.207
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1470.898
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1110.799
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1460.926
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0730.968
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3480.373
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3780.725
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2830.818
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9190.518
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.8660.345
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1920.132
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PDGFB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDGFB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDGFB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDGFB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDGFB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PDGFB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PDGFB and clinical features.
> Overall survival analysis
> Cancer stage
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Summary
SymbolPDGFB
Nameplatelet-derived growth factor beta polypeptide
Aliases SSV; oncogene SIS; becaplermin; SIS; platelet-derived growth factor beta polypeptide (simian sarcoma viral ( ......
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PDGFB collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PDGFB.
ID Name Drug Type Targets #Targets
DB06325PegpleranibSmall MoleculePDGFB1