Browse PDX1

Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm, cytosol
Domain PF00046 Homeobox domain
Function

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001678 cellular glucose homeostasis
GO:0001889 liver development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002067 glandular epithelial cell differentiation
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0003309 type B pancreatic cell differentiation
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0007224 smoothened signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007568 aging
GO:0007584 response to nutrient
GO:0009306 protein secretion
GO:0009730 detection of carbohydrate stimulus
GO:0009732 detection of hexose stimulus
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010039 response to iron ion
GO:0010040 response to iron(II) ion
GO:0010157 response to chlorate
GO:0010260 animal organ senescence
GO:0010817 regulation of hormone levels
GO:0015833 peptide transport
GO:0016331 morphogenesis of embryonic epithelium
GO:0019318 hexose metabolic process
GO:0019932 second-messenger-mediated signaling
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0031016 pancreas development
GO:0031017 exocrine pancreas development
GO:0031018 endocrine pancreas development
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0031667 response to nutrient levels
GO:0031960 response to corticosteroid
GO:0032024 positive regulation of insulin secretion
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0033273 response to vitamin
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0034287 detection of monosaccharide stimulus
GO:0034976 response to endoplasmic reticulum stress
GO:0035094 response to nicotine
GO:0035270 endocrine system development
GO:0035272 exocrine system development
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035883 enteroendocrine cell differentiation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043200 response to amino acid
GO:0043201 response to leucine
GO:0043279 response to alkaloid
GO:0043388 positive regulation of DNA binding
GO:0044723 single-organism carbohydrate metabolic process
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048732 gland development
GO:0048863 stem cell differentiation
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051047 positive regulation of secretion
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051101 regulation of DNA binding
GO:0051222 positive regulation of protein transport
GO:0051384 response to glucocorticoid
GO:0051594 detection of glucose
GO:0055123 digestive system development
GO:0060290 transdifferentiation
GO:0061008 hepaticobiliary system development
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070542 response to fatty acid
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:0097050 type B pancreatic cell apoptotic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1903532 positive regulation of secretion by cell
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904951 positive regulation of establishment of protein localization
GO:1990267 response to transition metal nanoparticle
GO:2000674 regulation of type B pancreatic cell apoptotic process
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001159 core promoter proximal region DNA binding
GO:0003682 chromatin binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0008134 transcription factor binding
GO:0046982 protein heterodimerization activity
Cellular Component GO:0016604 nuclear body
GO:0016607 nuclear speck
> KEGG and Reactome Pathway
 
KEGG hsa04911 Insulin secretion
Reactome R-HSA-1266738: Developmental Biology
R-HSA-186712: Regulation of beta-cell development
R-HSA-210745: Regulation of gene expression in beta cells
R-HSA-210747: Regulation of gene expression in early pancreatic precursor cells
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PDX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PDX1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PDX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8220.337
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.6960.363
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2810.903
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.050.904
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.050.937
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.9260.00384
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PDX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDX1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PDX1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PDX1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPDX1
Namepancreatic and duodenal homeobox 1
Aliases IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ......
Chromosomal Location13q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PDX1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.