Browse PIH1D1

Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF08190 pre-RNA processing PIH1/Nop17
Function

Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).

> Gene Ontology
 
Biological Process GO:0000491 small nucleolar ribonucleoprotein complex assembly
GO:0000492 box C/D snoRNP assembly
GO:0001678 cellular glucose homeostasis
GO:0006338 chromatin remodeling
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006360 transcription from RNA polymerase I promoter
GO:0006364 rRNA processing
GO:0006403 RNA localization
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006479 protein methylation
GO:0008213 protein alkylation
GO:0009303 rRNA transcription
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009756 carbohydrate mediated signaling
GO:0009757 hexose mediated signaling
GO:0010182 sugar mediated signaling pathway
GO:0010255 glucose mediated signaling pathway
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0016072 rRNA metabolic process
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0018022 peptidyl-lysine methylation
GO:0018023 peptidyl-lysine trimethylation
GO:0018027 peptidyl-lysine dimethylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0031056 regulation of histone modification
GO:0031057 negative regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031060 regulation of histone methylation
GO:0031061 negative regulation of histone methylation
GO:0031334 positive regulation of protein complex assembly
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032259 methylation
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0034284 response to monosaccharide
GO:0034470 ncRNA processing
GO:0034502 protein localization to chromosome
GO:0034968 histone lysine methylation
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0036123 histone H3-K9 dimethylation
GO:0036124 histone H3-K9 trimethylation
GO:0038202 TORC1 signaling
GO:0042254 ribosome biogenesis
GO:0042593 glucose homeostasis
GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043254 regulation of protein complex assembly
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043414 macromolecule methylation
GO:0043543 protein acylation
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0043970 histone H3-K9 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0044089 positive regulation of cellular component biogenesis
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
GO:0048254 snoRNA localization
GO:0051346 negative regulation of hydrolase activity
GO:0051567 histone H3-K9 methylation
GO:0051568 histone H3-K4 methylation
GO:0051569 regulation of histone H3-K4 methylation
GO:0051570 regulation of histone H3-K9 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0061647 histone H3-K9 modification
GO:0070199 establishment of protein localization to chromosome
GO:0071168 protein localization to chromatin
GO:0071169 establishment of protein localization to chromatin
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071826 ribonucleoprotein complex subunit organization
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090239 regulation of histone H4 acetylation
GO:0090240 positive regulation of histone H4 acetylation
GO:0090241 negative regulation of histone H4 acetylation
GO:0098781 ncRNA transcription
GO:1900109 regulation of histone H3-K9 dimethylation
GO:1900110 negative regulation of histone H3-K9 dimethylation
GO:1900112 regulation of histone H3-K9 trimethylation
GO:1900113 negative regulation of histone H3-K9 trimethylation
GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1901983 regulation of protein acetylation
GO:1901984 negative regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1902659 regulation of glucose mediated signaling pathway
GO:1902661 positive regulation of glucose mediated signaling pathway
GO:1903432 regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
GO:1905268 negative regulation of chromatin organization
GO:1905269 positive regulation of chromatin organization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000615 regulation of histone H3-K9 acetylation
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000618 regulation of histone H4-K16 acetylation
GO:2000619 negative regulation of histone H4-K16 acetylation
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Molecular Function GO:0001013 RNA polymerase I regulatory region DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding
GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding
GO:0042393 histone binding
GO:0051117 ATPase binding
GO:0051219 phosphoprotein binding
Cellular Component GO:0070761 pre-snoRNP complex
GO:0097255 R2TP complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PIH1D1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PIH1D1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.41; FDR: 0.02150 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PIH1D1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1020.694
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2310.93
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.350.851
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3460.259
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6250.745
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0060.998
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0640.836
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0110.994
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1620.92
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2510.896
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3120.914
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.060.366
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PIH1D1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIH1D1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIH1D1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIH1D1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIH1D1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PIH1D1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PIH1D1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPIH1D1
NamePIH1 domain containing 1
Aliases FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PIH1D1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.