Browse PPARGC1A

Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Nucleus. Nucleus, PML body.; SUBCELLULAR LOCATION: Isoform B4: Nucleus.; SUBCELLULAR LOCATION: Isoform B4-8a: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform B5: Nucleus. Nucleus, PML body.; SUBCELLULAR LOCATION: Isoform 9: Nucleus
Domain PF00076 RNA recognition motif. (a.k.a. RRM
Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

> Gene Ontology
 
Biological Process GO:0000002 mitochondrial genome maintenance
GO:0000266 mitochondrial fission
GO:0000302 response to reactive oxygen species
GO:0000422 mitophagy
GO:0001101 response to acid chemical
GO:0001659 temperature homeostasis
GO:0001666 response to hypoxia
GO:0001678 cellular glucose homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0002237 response to molecule of bacterial origin
GO:0002931 response to ischemia
GO:0003012 muscle system process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006012 galactose metabolic process
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006111 regulation of gluconeogenesis
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006631 fatty acid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006754 ATP biosynthetic process
GO:0006757 ATP generation from ADP
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007215 glutamate receptor signaling pathway
GO:0007568 aging
GO:0007586 digestion
GO:0007623 circadian rhythm
GO:0008202 steroid metabolic process
GO:0008207 C21-steroid hormone metabolic process
GO:0008209 androgen metabolic process
GO:0008380 RNA splicing
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009124 nucleoside monophosphate biosynthetic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009127 purine nucleoside monophosphate biosynthetic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009145 purine nucleoside triphosphate biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009206 purine ribonucleoside triphosphate biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009750 response to fructose
GO:0009755 hormone-mediated signaling pathway
GO:0009812 flavonoid metabolic process
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010469 regulation of receptor activity
GO:0010565 regulation of cellular ketone metabolic process
GO:0010566 regulation of ketone biosynthetic process
GO:0010639 negative regulation of organelle organization
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010677 negative regulation of cellular carbohydrate metabolic process
GO:0010817 regulation of hormone levels
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010823 negative regulation of mitochondrion organization
GO:0010893 positive regulation of steroid biosynthetic process
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0014074 response to purine-containing compound
GO:0014732 skeletal muscle atrophy
GO:0014812 muscle cell migration
GO:0014823 response to activity
GO:0014850 response to muscle activity
GO:0014874 response to stimulus involved in regulation of muscle adaptation
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014888 striated muscle adaptation
GO:0014889 muscle atrophy
GO:0014891 striated muscle atrophy
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016051 carbohydrate biosynthetic process
GO:0016052 carbohydrate catabolic process
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0019362 pyridine nucleotide metabolic process
GO:0019395 fatty acid oxidation
GO:0021549 cerebellum development
GO:0022037 metencephalon development
GO:0022898 regulation of transmembrane transporter activity
GO:0022900 electron transport chain
GO:0022904 respiratory electron transport chain
GO:0030258 lipid modification
GO:0030336 negative regulation of cell migration
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031000 response to caffeine
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031647 regulation of protein stability
GO:0031667 response to nutrient levels
GO:0032042 mitochondrial DNA metabolic process
GO:0032350 regulation of hormone metabolic process
GO:0032352 positive regulation of hormone metabolic process
GO:0032354 response to follicle-stimulating hormone
GO:0032355 response to estradiol
GO:0032409 regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032922 circadian regulation of gene expression
GO:0033002 muscle cell proliferation
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0034440 lipid oxidation
GO:0034599 cellular response to oxidative stress
GO:0034612 response to tumor necrosis factor
GO:0034698 response to gonadotropin
GO:0034754 cellular hormone metabolic process
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0035634 response to stilbenoid
GO:0035864 response to potassium ion
GO:0035865 cellular response to potassium ion
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0042180 cellular ketone metabolic process
GO:0042181 ketone biosynthetic process
GO:0042278 purine nucleoside metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042440 pigment metabolic process
GO:0042445 hormone metabolic process
GO:0042446 hormone biosynthetic process
GO:0042448 progesterone metabolic process
GO:0042451 purine nucleoside biosynthetic process
GO:0042455 ribonucleoside biosynthetic process
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0043200 response to amino acid
GO:0043201 response to leucine
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043279 response to alkaloid
GO:0043401 steroid hormone mediated signaling pathway
GO:0043457 regulation of cellular respiration
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043470 regulation of carbohydrate catabolic process
GO:0043500 muscle adaptation
GO:0043501 skeletal muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043543 protein acylation
GO:0044057 regulation of system process
GO:0044236 multicellular organism metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045333 cellular respiration
GO:0045444 fat cell differentiation
GO:0045472 response to ether
GO:0045722 positive regulation of gluconeogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045912 negative regulation of carbohydrate metabolic process
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045940 positive regulation of steroid metabolic process
GO:0045978 negative regulation of nucleoside metabolic process
GO:0045979 positive regulation of nucleoside metabolic process
GO:0045980 negative regulation of nucleotide metabolic process
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046129 purine ribonucleoside biosynthetic process
GO:0046320 regulation of fatty acid oxidation
GO:0046321 positive regulation of fatty acid oxidation
GO:0046364 monosaccharide biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046885 regulation of hormone biosynthetic process
GO:0046886 positive regulation of hormone biosynthetic process
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0046939 nucleotide phosphorylation
GO:0048511 rhythmic process
GO:0048545 response to steroid hormone
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048871 multicellular organismal homeostasis
GO:0050810 regulation of steroid biosynthetic process
GO:0050821 protein stabilization
GO:0050873 brown fat cell differentiation
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051186 cofactor metabolic process
GO:0051193 regulation of cofactor metabolic process
GO:0051195 negative regulation of cofactor metabolic process
GO:0051196 regulation of coenzyme metabolic process
GO:0051198 negative regulation of coenzyme metabolic process
GO:0051271 negative regulation of cellular component movement
GO:0051402 neuron apoptotic process
GO:0051552 flavone metabolic process
GO:0051602 response to electrical stimulus
GO:0060537 muscle tissue development
GO:0060612 adipose tissue development
GO:0061448 connective tissue development
GO:0061726 mitochondrion disassembly
GO:0070482 response to oxygen levels
GO:0070542 response to fatty acid
GO:0070741 response to interleukin-6
GO:0070997 neuron death
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071229 cellular response to acid chemical
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071250 cellular response to nitrite
GO:0071312 cellular response to alkaloid
GO:0071313 cellular response to caffeine
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071362 cellular response to ether
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071396 cellular response to lipid
GO:0071398 cellular response to fatty acid
GO:0071407 cellular response to organic cyclic compound
GO:0071415 cellular response to purine-containing compound
GO:0071417 cellular response to organonitrogen compound
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071867 response to monoamine
GO:0071869 response to catecholamine
GO:0071871 response to epinephrine
GO:0071873 response to norepinephrine
GO:0072522 purine-containing compound biosynthetic process
GO:0072524 pyridine-containing compound metabolic process
GO:0080033 response to nitrite
GO:0090140 regulation of mitochondrial fission
GO:0090257 regulation of muscle system process
GO:0090258 negative regulation of mitochondrial fission
GO:0097009 energy homeostasis
GO:0097066 response to thyroid hormone
GO:0097067 cellular response to thyroid hormone stimulus
GO:0099601 regulation of neurotransmitter receptor activity
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900543 negative regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901558 response to metformin
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
GO:1901857 positive regulation of cellular respiration
GO:1901858 regulation of mitochondrial DNA metabolic process
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1901983 regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902170 cellular response to reactive nitrogen species
GO:1902275 regulation of chromatin organization
GO:1903008 organelle disassembly
GO:1903210 glomerular visceral epithelial cell apoptotic process
GO:1903578 regulation of ATP metabolic process
GO:1903579 negative regulation of ATP metabolic process
GO:1903580 positive regulation of ATP metabolic process
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1904633 regulation of glomerular visceral epithelial cell apoptotic process
GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process
GO:1904636 response to ionomycin
GO:1904637 cellular response to ionomycin
GO:1904638 response to resveratrol
GO:1904639 cellular response to resveratrol
GO:1904640 response to methionine
GO:1905269 positive regulation of chromatin organization
GO:1990845 adaptive thermogenesis
GO:2000146 negative regulation of cell motility
GO:2000182 regulation of progesterone biosynthetic process
GO:2000184 positive regulation of progesterone biosynthetic process
GO:2000272 negative regulation of receptor activity
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000505 regulation of energy homeostasis
GO:2000507 positive regulation of energy homeostasis
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
GO:2001169 regulation of ATP biosynthetic process
GO:2001171 positive regulation of ATP biosynthetic process
Molecular Function GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0008134 transcription factor binding
GO:0015631 tubulin binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0035257 nuclear hormone receptor binding
GO:0035258 steroid hormone receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043014 alpha-tubulin binding
GO:0043566 structure-specific DNA binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0050681 androgen receptor binding
GO:0051427 hormone receptor binding
GO:1990841 promoter-specific chromatin binding
Cellular Component GO:0000428 DNA-directed RNA polymerase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000791 euchromatin
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005719 nuclear euchromatin
GO:0005840 ribosome
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0016604 nuclear body
GO:0016605 PML body
GO:0022626 cytosolic ribosome
GO:0030425 dendrite
GO:0030880 RNA polymerase complex
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044445 cytosolic part
GO:0044454 nuclear chromosome part
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0097440 apical dendrite
GO:1990843 subsarcolemmal mitochondrion
GO:1990844 interfibrillar mitochondrion
> KEGG and Reactome Pathway
 
KEGG hsa04152 AMPK signaling pathway
hsa04910 Insulin signaling pathway
hsa04920 Adipocytokine signaling pathway
hsa04922 Glucagon signaling pathway
Reactome R-HSA-2151209: Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-1368108: BMAL1
R-HSA-400253: Circadian Clock
R-HSA-1266738: Developmental Biology
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-1368082: RORA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPARGC1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPARGC1A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPARGC1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2710.602
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6560.442
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0250.975
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.20.66
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.110.935
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3090.842
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.390.648
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0970.945
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5110.71
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.0970.203
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8160.463
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.9980.00346
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PPARGC1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.48.2-0.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.410.2-2.81
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.817.6-12.80.307
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.727.3-19.60.3
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPARGC1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPARGC1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPARGC1A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPARGC1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPARGC1A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPARGC1A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPARGC1A
Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ......
Chromosomal Location4p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPARGC1A collected from DrugBank database.
> Drugs from DrugBank database
 

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