TISIDB

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm
Domain	-
Function	B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0006470 protein dephosphorylation GO:0007067 mitotic nuclear division GO:0010458 exit from mitosis GO:0010921 regulation of phosphatase activity GO:0016311 dephosphorylation GO:0034047 regulation of protein phosphatase type 2A activity GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0043666 regulation of phosphoprotein phosphatase activity GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0070262 peptidyl-serine dephosphorylation
Molecular Function	GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0008601 protein phosphatase type 2A regulator activity GO:0016791 phosphatase activity GO:0019208 phosphatase regulator activity GO:0019888 protein phosphatase regulator activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	GO:0000159 protein phosphatase type 2A complex GO:0008287 protein serine/threonine phosphatase complex GO:1903293 phosphatase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03015 mRNA surveillance pathway hsa04071 Sphingolipid signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04390 Hippo signaling pathway hsa04530 Tight junction hsa04728 Dopaminergic synapse
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-68886: M Phase R-HSA-2465910: MASTL Facilitates Mitotic Progression R-HSA-68875: Mitotic Prophase

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPP2R2D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between PPP2R2D and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
24476824	Melanoma	Inhibit immunity (T cell function)	In tumours, Ppp2r2d knockdown inhibited T-cell apoptosis and enhanced T-cell proliferation as well as cytokine production.

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PPP2R2D in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	Total # shRNA with >= 4-fold: 5	Resistant to T-cell proliferation

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PPP2R2D in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.016	0.925
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.125	0.905
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.061	0.935
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.054	0.837
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.116	0.947
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.02	0.993
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.031	0.919
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.043	0.972
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.022	0.987
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.236	0.847
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.076	0.966
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.052	0.46

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PPP2R2D in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	2.7	-2.7	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP2R2D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP2R2D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP2R2D. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP2R2D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPP2R2D expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPP2R2D and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPP2R2D
Name	protein phosphatase 2, regulatory subunit B, delta
Aliases	MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPP2R2D collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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