Browse PTCH1

Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein.
Domain PF02460 Patched family
Function

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

> Gene Ontology
 
Biological Process GO:0000578 embryonic axis specification
GO:0001101 response to acid chemical
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001838 embryonic epithelial tube formation
GO:0001840 neural plate development
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0006612 protein targeting to membrane
GO:0006869 lipid transport
GO:0007009 plasma membrane organization
GO:0007224 smoothened signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009798 axis specification
GO:0009880 embryonic pattern specification
GO:0009913 epidermal cell differentiation
GO:0009953 dorsal/ventral pattern formation
GO:0009957 epidermal cell fate specification
GO:0010035 response to inorganic substance
GO:0010157 response to chlorate
GO:0010874 regulation of cholesterol efflux
GO:0010875 positive regulation of cholesterol efflux
GO:0010876 lipid localization
GO:0014020 primary neural tube formation
GO:0015850 organic hydroxy compound transport
GO:0015918 sterol transport
GO:0016331 morphogenesis of embryonic epithelium
GO:0016485 protein processing
GO:0021510 spinal cord development
GO:0021515 cell differentiation in spinal cord
GO:0021517 ventral spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021532 neural tube patterning
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0021953 central nervous system neuron differentiation
GO:0021997 neural plate axis specification
GO:0022612 gland morphogenesis
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030301 cholesterol transport
GO:0030326 embryonic limb morphogenesis
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0032355 response to estradiol
GO:0032368 regulation of lipid transport
GO:0032370 positive regulation of lipid transport
GO:0032371 regulation of sterol transport
GO:0032373 positive regulation of sterol transport
GO:0032374 regulation of cholesterol transport
GO:0032376 positive regulation of cholesterol transport
GO:0032526 response to retinoic acid
GO:0033344 cholesterol efflux
GO:0033500 carbohydrate homeostasis
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035264 multicellular organism growth
GO:0036314 response to sterol
GO:0036315 cellular response to sterol
GO:0040014 regulation of multicellular organism growth
GO:0040015 negative regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616 keratinocyte proliferation
GO:0045165 cell fate commitment
GO:0045604 regulation of epidermal cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045682 regulation of epidermis development
GO:0045684 positive regulation of epidermis development
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045926 negative regulation of growth
GO:0048568 embryonic organ development
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048732 gland development
GO:0048736 appendage development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051302 regulation of cell division
GO:0051604 protein maturation
GO:0051782 negative regulation of cell division
GO:0060037 pharyngeal system development
GO:0060173 limb development
GO:0060443 mammary gland morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0060606 tube closure
GO:0060644 mammary gland epithelial cell differentiation
GO:0060675 ureteric bud morphogenesis
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060896 neural plate pattern specification
GO:0060993 kidney morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061053 somite development
GO:0061138 morphogenesis of a branching epithelium
GO:0061180 mammary gland epithelium development
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0070723 response to cholesterol
GO:0071396 cellular response to lipid
GO:0071397 cellular response to cholesterol
GO:0071407 cellular response to organic cyclic compound
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072111 cell proliferation involved in kidney development
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072175 epithelial tube formation
GO:0072203 cell proliferation involved in metanephros development
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:1990778 protein localization to cell periphery
Molecular Function GO:0005113 patched binding
GO:0005119 smoothened binding
GO:0005496 steroid binding
GO:0005539 glycosaminoglycan binding
GO:0008158 hedgehog receptor activity
GO:0008201 heparin binding
GO:0015485 cholesterol binding
GO:0030332 cyclin binding
GO:0032934 sterol binding
GO:0043178 alcohol binding
GO:0097108 hedgehog family protein binding
GO:1901681 sulfur compound binding
Cellular Component GO:0005901 caveola
GO:0005929 cilium
GO:0014069 postsynaptic density
GO:0030139 endocytic vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0030496 midbody
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0031253 cell projection membrane
GO:0033267 axon part
GO:0044292 dendrite terminus
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0044441 ciliary part
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0060076 excitatory synapse
GO:0060170 ciliary membrane
GO:0072372 primary cilium
GO:0098589 membrane region
GO:0098794 postsynapse
GO:0098857 membrane microdomain
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG hsa04024 cAMP signaling pathway
hsa04340 Hedgehog signaling pathway
hsa04360 Axon guidance
Reactome R-HSA-5635838: Activation of SMO
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-5635851: GLI proteins bind promoters of Hh responsive genes to promote transcription
R-HSA-500792: GPCR ligand binding
R-HSA-5610787: Hedgehog 'off' state
R-HSA-5632684: Hedgehog 'on' state
R-HSA-5632681: Ligand-receptor interactions
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTCH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTCH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTCH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1620.639
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1580.838
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1650.79
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4940.114
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6880.741
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2490.925
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6720.0628
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.9350.411
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4380.716
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1540.888
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3760.292
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0580.581
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTCH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTCH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTCH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTCH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTCH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTCH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTCH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTCH1
Namepatched 1
Aliases BCNS; NBCCS; PTCH; patched (Drosophila) homolog; patched homolog (Drosophila); patched homolog 1 (Drosophila ......
Chromosomal Location9q22.1-q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTCH1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.