Browse PTH1R

Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00002 7 transmembrane receptor (Secretin family)
PF02793 Hormone receptor domain
Function

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001894 tissue homeostasis
GO:0002062 chondrocyte differentiation
GO:0002076 osteoblast development
GO:0006066 alcohol metabolic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007568 aging
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010919 regulation of inositol phosphate biosynthetic process
GO:0016051 carbohydrate biosynthetic process
GO:0019751 polyol metabolic process
GO:0021700 developmental maturation
GO:0030282 bone mineralization
GO:0031214 biomineral tissue development
GO:0032958 inositol phosphate biosynthetic process
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045453 bone resorption
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0046165 alcohol biosynthetic process
GO:0046173 polyol biosynthetic process
GO:0046849 bone remodeling
GO:0048469 cell maturation
GO:0048771 tissue remodeling
GO:0048871 multicellular organismal homeostasis
GO:0051216 cartilage development
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055074 calcium ion homeostasis
GO:0060249 anatomical structure homeostasis
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0061448 connective tissue development
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1902930 regulation of alcohol biosynthetic process
GO:1902932 positive regulation of alcohol biosynthetic process
Molecular Function GO:0004991 parathyroid hormone receptor activity
GO:0017046 peptide hormone binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0042562 hormone binding
GO:0043621 protein self-association
Cellular Component GO:0005903 brush border
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031253 cell projection membrane
GO:0031526 brush border membrane
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0098862 cluster of actin-based cell projections
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04961 Endocrine and other factor-regulated calcium reabsorption
Reactome R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTH1R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTH1R in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTH1R in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.840.0393
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.0010.00173
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0020.998
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.860.185
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4680.774
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3440.438
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6940.202
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.3160.102
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0310.971
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1770.889
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.690.687
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6280.00121
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTH1R in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTH1R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTH1R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTH1R.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTH1R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTH1R expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTH1R and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTH1R
Nameparathyroid hormone 1 receptor
Aliases PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ......
Chromosomal Location3p22-p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTH1R collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PTH1R.
ID Name Drug Type Targets #Targets
DB05084AbaloparatideBiotechPTH1R1
DB05829Parathyroid hormoneBiotechPTH1R, PTH2R2
DB06285TeriparatideBiotechPTH1R1