Browse PTPN2

Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. ; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane.
Domain PF00102 Protein-tyrosine phosphatase
Function

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.

> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002262 myeloid cell homeostasis
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002757 immune response-activating signal transduction
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006109 regulation of carbohydrate metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0008286 insulin receptor signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010876 lipid localization
GO:0010883 regulation of lipid storage
GO:0010888 negative regulation of lipid storage
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0016051 carbohydrate biosynthetic process
GO:0016311 dephosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0019915 lipid storage
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031348 negative regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033077 T cell differentiation in thymus
GO:0033081 regulation of T cell differentiation in thymus
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033500 carbohydrate homeostasis
GO:0033673 negative regulation of kinase activity
GO:0034101 erythrocyte homeostasis
GO:0034340 response to type I interferon
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035771 interleukin-4-mediated signaling pathway
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036005 response to macrophage colony-stimulating factor
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0036499 PERK-mediated unfolded protein response
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038127 ERBB signaling pathway
GO:0038145 macrophage colony-stimulating factor signaling pathway
GO:0038161 prolactin signaling pathway
GO:0040013 negative regulation of locomotion
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042326 negative regulation of phosphorylation
GO:0042505 tyrosine phosphorylation of Stat6 protein
GO:0042506 tyrosine phosphorylation of Stat5 protein
GO:0042508 tyrosine phosphorylation of Stat1 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042512 negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042525 regulation of tyrosine phosphorylation of Stat6 protein
GO:0042527 negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043368 positive T cell selection
GO:0043409 negative regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0044262 cellular carbohydrate metabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045058 T cell selection
GO:0045059 positive thymic T cell selection
GO:0045061 thymic T cell selection
GO:0045088 regulation of innate immune response
GO:0045580 regulation of T cell differentiation
GO:0045581 negative regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045620 negative regulation of lymphocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045649 regulation of macrophage differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045824 negative regulation of innate immune response
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0046364 monosaccharide biosynthetic process
GO:0046425 regulation of JAK-STAT cascade
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048872 homeostasis of number of cells
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050777 negative regulation of immune response
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050854 regulation of antigen receptor-mediated signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050858 negative regulation of antigen receptor-mediated signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0050920 regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0051235 maintenance of location
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051348 negative regulation of transferase activity
GO:0060330 regulation of response to interferon-gamma
GO:0060331 negative regulation of response to interferon-gamma
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0060759 regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070103 regulation of interleukin-6-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070741 response to interleukin-6
GO:0071346 cellular response to interferon-gamma
GO:0071352 cellular response to interleukin-2
GO:0071353 cellular response to interleukin-4
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071357 cellular response to type I interferon
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097696 STAT cascade
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1900101 regulation of endoplasmic reticulum unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901184 regulation of ERBB signaling pathway
GO:1901185 negative regulation of ERBB signaling pathway
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902205 regulation of interleukin-2-mediated signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902211 regulation of prolactin signaling pathway
GO:1902212 negative regulation of prolactin signaling pathway
GO:1902214 regulation of interleukin-4-mediated signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902232 regulation of positive thymic T cell selection
GO:1902233 negative regulation of positive thymic T cell selection
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903897 regulation of PERK-mediated unfolded protein response
GO:1903899 positive regulation of PERK-mediated unfolded protein response
GO:1903969 regulation of response to macrophage colony-stimulating factor
GO:1903970 negative regulation of response to macrophage colony-stimulating factor
GO:1903972 regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1903973 negative regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1904892 regulation of STAT cascade
GO:1904893 negative regulation of STAT cascade
GO:2000398 regulation of thymocyte aggregation
GO:2000399 negative regulation of thymocyte aggregation
GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0000149 SNARE binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0016791 phosphatase activity
GO:0019905 syntaxin binding
GO:0030971 receptor tyrosine kinase binding
GO:0042578 phosphoric ester hydrolase activity
GO:0050839 cell adhesion molecule binding
GO:1990782 protein tyrosine kinase binding
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
> KEGG and Reactome Pathway
 
KEGG hsa04630 Jak-STAT signaling pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-913531: Interferon Signaling
R-HSA-877300: Interferon gamma signaling
R-HSA-6807004: Negative regulation of MET activity
R-HSA-877312: Regulation of IFNG signaling
R-HSA-162582: Signal Transduction
R-HSA-6806834: Signaling by MET
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTPN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PTPN2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28723893Melanoma; lung carcinoma; colon carcinomaInhibit immunity; resistant to immunotherapyTumours were sensitized to immunotherapy by deletion of genes involved in several diverse pathways, including NF-κB signalling, antigen presentation and the unfolded protein response. Loss of PTPN2 lead to alteration in NK-kB signaling, antigen presentaion and unfolded protein reponse, thus, sensitive to immunotherapy.
29764444GliomaInhibit immunitySpecifically, PTPN2 was positively associated with HCK, LCK, MHC II, and STAT1 but negatively related to IgG and interferon. Moreover, canonical correlation analysis showed a positive correlation of PTPN2 with infiltrating immune cells, such as macrophages, neutrophils, and CD8+ T cells. Clinically, higher levels of PTPN2 were associated with a worse overall survival both in patients with gliomas and glioblastomas.
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTPN2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -3.22; FDR: 0.00700 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -3.63; FDR: 0.00248 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 6.45; FDR: 0.000 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 8.52; FDR: 0.000 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 5 Resistant to T-cell proliferation
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTPN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0470.836
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0070.997
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0840.952
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0720.788
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1290.943
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0011
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1360.679
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2510.863
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0120.994
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2090.876
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1310.95
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.020.752
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTPN2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTPN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTPN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTPN2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTPN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTPN2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTPN2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTPN2
Nameprotein tyrosine phosphatase, non-receptor type 2
Aliases TCELLPTP; TC-PTP; TCPTP; PTPT; PTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatas ......
Chromosomal Location18p11.3-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTPN2 collected from DrugBank database.
> Drugs from DrugBank database
 

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