Browse RAB17

Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Recycling endosome membrane Lipid-anchor Cytoplasmic side Melanosome Cell projection, dendrite Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.
Domain PF00071 Ras family
Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

> Gene Ontology
 
Biological Process GO:0002251 organ or tissue specific immune response
GO:0002385 mucosal immune response
GO:0002386 immune response in mucosal-associated lymphoid tissue
GO:0002414 immunoglobulin transcytosis in epithelial cells
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0007034 vacuolar transport
GO:0007416 synapse assembly
GO:0010927 cellular component assembly involved in morphogenesis
GO:0010975 regulation of neuron projection development
GO:0016197 endosomal transport
GO:0016358 dendrite development
GO:0030031 cell projection assembly
GO:0030100 regulation of endocytosis
GO:0032400 melanosome localization
GO:0032401 establishment of melanosome localization
GO:0032402 melanosome transport
GO:0032456 endocytic recycling
GO:0033059 cellular pigmentation
GO:0042384 cilium assembly
GO:0043473 pigmentation
GO:0044782 cilium organization
GO:0045056 transcytosis
GO:0046847 filopodium assembly
GO:0050773 regulation of dendrite development
GO:0050803 regulation of synapse structure or activity
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0051489 regulation of filopodium assembly
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051875 pigment granule localization
GO:0051904 pigment granule transport
GO:0051905 establishment of pigment granule localization
GO:0051963 regulation of synapse assembly
GO:0060271 cilium morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0060627 regulation of vesicle-mediated transport
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0005769 early endosome
GO:0010008 endosome membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0030425 dendrite
GO:0042470 melanosome
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044440 endosomal part
GO:0045177 apical part of cell
GO:0048770 pigment granule
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8873719: RAB geranylgeranylation
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB17 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB17 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.6730.00366
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)652.1380.299
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.3340.394
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6770.0926
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7240.557
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6150.674
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3410.594
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3460.79
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2170.889
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.2170.453
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.7930.443
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0460.818
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB17.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB17 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB17 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB17
NameRAB17, member RAS oncogene family
Aliases Ras-related protein Rab-17
Chromosomal Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB17 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.