Browse RAD21L1

Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Chromosome Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements.
Domain PF04824 Conserved region of Rad21 / Rec8 like protein
PF04825 N terminus of Rad21 / Rec8 like protein
Function

Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0000819 sister chromatid segregation
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007129 synapsis
GO:0007130 synaptonemal complex assembly
GO:0007135 meiosis II
GO:0007283 spermatogenesis
GO:0007548 sex differentiation
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009566 fertilization
GO:0034397 telomere localization
GO:0034398 telomere tethering at nuclear periphery
GO:0044821 meiotic telomere tethering at nuclear periphery
GO:0045132 meiotic chromosome segregation
GO:0045137 development of primary sexual characteristics
GO:0045141 meiotic telomere clustering
GO:0045143 homologous chromosome segregation
GO:0045144 meiotic sister chromatid segregation
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0048232 male gamete generation
GO:0048608 reproductive structure development
GO:0050000 chromosome localization
GO:0051177 meiotic sister chromatid cohesion
GO:0051303 establishment of chromosome localization
GO:0051321 meiotic cell cycle
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0051754 meiotic sister chromatid cohesion, centromeric
GO:0061458 reproductive system development
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0070193 synaptonemal complex organization
GO:0070197 meiotic attachment of telomere to nuclear envelope
GO:0070601 centromeric sister chromatid cohesion
GO:0072520 seminiferous tubule development
GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation
GO:0097240 chromosome attachment to the nuclear envelope
GO:0098813 nuclear chromosome segregation
GO:1903046 meiotic cell cycle process
Molecular Function GO:0003682 chromatin binding
Cellular Component GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0000798 nuclear cohesin complex
GO:0000800 lateral element
GO:0008278 cohesin complex
GO:0030893 meiotic cohesin complex
GO:0034991 nuclear meiotic cohesin complex
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAD21L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAD21L1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAD21L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7170.402
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0540.966
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.6970.228
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.10.816
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.10.876
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6250.0112
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAD21L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAD21L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAD21L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAD21L1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAD21L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAD21L1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAD21L1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAD21L1
NameRAD21 cohesin complex component like 1
Aliases dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAD21L1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.