Browse RSF1

Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00628 PHD-finger
PF15612 WSTF
Function

Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).

> Gene Ontology
 
Biological Process GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006352 DNA-templated transcription, initiation
GO:0016584 nucleosome positioning
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0031055 chromatin remodeling at centromere
GO:0031497 chromatin assembly
GO:0034080 CENP-A containing nucleosome assembly
GO:0034508 centromere complex assembly
GO:0034724 DNA replication-independent nucleosome organization
GO:0034728 nucleosome organization
GO:0043044 ATP-dependent chromatin remodeling
GO:0043392 negative regulation of DNA binding
GO:0043486 histone exchange
GO:0043900 regulation of multi-organism process
GO:0043902 positive regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044033 multi-organism metabolic process
GO:0046782 regulation of viral transcription
GO:0048524 positive regulation of viral process
GO:0050434 positive regulation of viral transcription
GO:0050792 regulation of viral process
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051101 regulation of DNA binding
GO:0061641 CENP-A containing chromatin organization
GO:0065004 protein-DNA complex assembly
GO:0071103 DNA conformation change
GO:0071824 protein-DNA complex subunit organization
GO:1903900 regulation of viral life cycle
GO:1903902 positive regulation of viral life cycle
Molecular Function GO:0042393 histone binding
Cellular Component GO:0031010 ISWI-type complex
GO:0031213 RSF complex
GO:0070603 SWI/SNF superfamily-type complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-73886: Chromosome Maintenance
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-774815: Nucleosome assembly
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RSF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RSF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.35; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RSF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0560.885
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4980.708
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2790.812
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1170.625
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1240.96
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1090.972
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.140.729
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3860.803
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.070.966
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4410.678
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8390.584
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0610.221
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RSF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916018.8-18.80.28
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RSF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RSF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RSF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RSF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RSF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RSF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRSF1
Nameremodeling and spacing factor 1
Aliases XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Chromosomal Location11q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RSF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.