Browse SEMA6B

Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Domain PF01437 Plexin repeat
PF01403 Sema domain
Function

May play a role in both peripheral and central nervous system development.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0001667 ameboidal-type cell migration
GO:0001755 neural crest cell migration
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0008361 regulation of cell size
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0016049 cell growth
GO:0022604 regulation of cell morphogenesis
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030516 regulation of axon extension
GO:0030517 negative regulation of axon extension
GO:0031345 negative regulation of cell projection organization
GO:0032102 negative regulation of response to external stimulus
GO:0032535 regulation of cellular component size
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0045665 negative regulation of neuron differentiation
GO:0045926 negative regulation of growth
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048762 mesenchymal cell differentiation
GO:0048841 regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050919 negative chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051961 negative regulation of nervous system development
GO:0060485 mesenchyme development
GO:0060560 developmental growth involved in morphogenesis
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0071526 semaphorin-plexin signaling pathway
GO:0090066 regulation of anatomical structure size
GO:0097485 neuron projection guidance
GO:1902284 neuron projection extension involved in neuron projection guidance
GO:1902667 regulation of axon guidance
GO:1902668 negative regulation of axon guidance
GO:1990138 neuron projection extension
GO:2000147 positive regulation of cell motility
Molecular Function GO:0030215 semaphorin receptor binding
GO:0045499 chemorepellent activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
Reactome -
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SEMA6B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SEMA6B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.67 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SEMA6B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0850.0579
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6290.735
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.3930.195
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.390.421
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8460.644
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1820.934
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.070.904
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4570.691
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4130.728
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3580.773
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.240.441
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2010.164
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SEMA6B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.125-13.90.621
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592022.2-2.21
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47028.6-28.60.491
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEMA6B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEMA6B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEMA6B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEMA6B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SEMA6B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SEMA6B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSEMA6B
Namesema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Aliases semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SEMA6B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.