Browse SERPINB2

Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Secreted, extracellular space.
Domain PF00079 Serpin (serine protease inhibitor)
Function

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

> Gene Ontology
 
Biological Process GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0032102 negative regulation of response to external stimulus
GO:0042730 fibrinolysis
GO:0045861 negative regulation of proteolysis
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050819 negative regulation of coagulation
GO:0050878 regulation of body fluid levels
GO:0051346 negative regulation of hydrolase activity
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:1900046 regulation of hemostasis
GO:1900047 negative regulation of hemostasis
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
Molecular Function GO:0004857 enzyme inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
GO:0061134 peptidase regulator activity
GO:0061135 endopeptidase regulator activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04610 Complement and coagulation cascades
Reactome R-HSA-75205: Dissolution of Fibrin Clot
R-HSA-109582: Hemostasis
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SERPINB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SERPINB2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SERPINB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6830.373
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.0840.0877
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3450.744
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.9230.0352
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.4060.305
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-2.5810.0885
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6870.462
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6770.628
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8130.572
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2340.539
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2340.691
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2760.507
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SERPINB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINB2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SERPINB2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SERPINB2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSERPINB2
Nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
Aliases HsT1201; PLANH2; PAI2; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; PAI-2; mono ......
Chromosomal Location18q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SERPINB2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SERPINB2.
ID Name Drug Type Targets #Targets
DB00013UrokinaseBiotechLRP2, NID1, PLAT, PLAU, PLAUR, PLG, SERPINA5, SERPINB2, SERPINE1, ......10
DB00031TenecteplaseBiotechANXA2, CALR, CANX, CLEC3B, FGA, KRT8, LRP1, PLAUR, PLG, SERPINB2, ......11
DB06245LanoteplaseBiotechANXA2, CALR, CANX, CLEC3B, F10, FGA, FN1, KLK1, KRT8, LAMA1, LAMA3 ......17