Browse SLC17A3

Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Endoplasmic reticulum membrane Multi-pass membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Multi-pass membrane protein
Domain PF07690 Major Facilitator Superfamily
Function

Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.

> Gene Ontology
 
Biological Process GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0006820 anion transport
GO:0006855 drug transmembrane transport
GO:0015672 monovalent inorganic cation transport
GO:0015698 inorganic anion transport
GO:0015711 organic anion transport
GO:0015712 hexose phosphate transport
GO:0015747 urate transport
GO:0015748 organophosphate ester transport
GO:0015760 glucose-6-phosphate transport
GO:0015849 organic acid transport
GO:0015893 drug transport
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035435 phosphate ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042493 response to drug
GO:0044070 regulation of anion transport
GO:0044341 sodium-dependent phosphate transport
GO:0046415 urate metabolic process
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1901264 carbohydrate derivative transport
GO:1901998 toxin transport
GO:1903825 organic acid transmembrane transport
GO:1903959 regulation of anion transmembrane transport
Molecular Function GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005253 anion channel activity
GO:0005342 organic acid transmembrane transporter activity
GO:0005436 sodium:phosphate symporter activity
GO:0008308 voltage-gated anion channel activity
GO:0008509 anion transmembrane transporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015114 phosphate ion transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015238 drug transmembrane transporter activity
GO:0015267 channel activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015294 solute:cation symporter activity
GO:0015296 anion:cation symporter activity
GO:0015321 sodium-dependent phosphate transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0019534 toxin transporter activity
GO:0022803 passive transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022853 active ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
GO:0090484 drug transporter activity
GO:1901702 salt transmembrane transporter activity
Cellular Component GO:0005903 brush border
GO:0016324 apical plasma membrane
GO:0031253 cell projection membrane
GO:0031526 brush border membrane
GO:0045177 apical part of cell
GO:0098862 cluster of actin-based cell projections
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-983712: Ion channel transport
R-HSA-2672351: Stimuli-sensing channels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC17A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC17A3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC17A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1370.436
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.240.589
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5690.574
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.8210.2
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9950.532
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0670.93
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4310.818
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5830.743
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1020.679
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0590.988
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8330.0166
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC17A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.514.8-4.30.709
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.615.4-1.81
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.214.3-8.10.586
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC17A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC17A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC17A3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC17A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC17A3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC17A3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC17A3
Namesolute carrier family 17 (organic anion transporter), member 3
Aliases NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ......
Chromosomal Location6p22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC17A3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.